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Sponsored by: |
Hamilton Health Sciences |
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Information provided by: | McMaster University |
ClinicalTrials.gov Identifier: | NCT00662467 |
Following severe heart attacks involving the front wall of the heart (anterior myocardial infarction), patients are at risk of developing blood clots in the main pumping chamber that can cause a stroke. In the past, studies have shown that a blood thinner (warfarin) can decrease the risk of stroke and clot formation if administered to patients after an anterior myocardial infarction.
However, in today's current practice, certain heart attack patients are commonly treated with two blood-thinning medications (aspirin and clopidogrel) to prevent recurrent heart attacks.
Thus, a clinical problem is created as physicians are not clear how to treat patients after an anterior myocardial infarction who are at risk of a clot but require aspirin and clopidogrel to keep their blood vessels open. Adding warfarin to the combination of aspirin and clopidogrel will possibly decrease the risk of stroke but increase the risk of bleeding. Currently, there is no good evidence to help guide physicians. As demonstrated by a survey done at the Hamilton Health Sciences, there is a fifty/fifty split between physicians who use dual (aspirin and clopidogrel) versus triple (aspirin, clopidogrel, and warfarin) therapy in the treatment of similar patients as described above.
The purpose of this study is to address the bleeding and stroke complications in patients after a severe anterior myocardial infarction. Half of the eligible patients will receive dual therapy and half will receive triple therapy. We will compare the incidence of stroke, blood clots, and bleeding complications between the two groups at 3 months.
Condition | Intervention |
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Myocardial Infarction |
Drug: aspirin + clopidogrel Drug: aspirin + clopidogrel + warfarin |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Safety/Efficacy Study |
Official Title: | Warfarin After Anterior ST-Elevation Myocardial Infarction |
Enrollment: | 20 |
Study Start Date: | November 2006 |
Study Completion Date: | January 2008 |
Primary Completion Date: | January 2008 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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1: Active Comparator
aspirin and clopidogrel
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Drug: aspirin + clopidogrel
Dual therapy
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2: Experimental
aspirin, clopidogrel, and warfarin
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Drug: aspirin + clopidogrel + warfarin
Triple therapy
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Rationale:
Left ventricular mural thrombus (LVT) remains a common complication after anterior ST-elevation myocardial infarction (STEMI) with a reported incidence ranging from 12- 17%. Previous studies from the pre-thrombolytic era have shown that warfarin therapy significantly reduces the incidence of LVT and embolic events in patients post anterior STEMI. However, the risk/benefit ratio of warfarin therapy in the setting of early revascularization and dual antiplatelet therapy with aspirin and clopidogrel remains unknown.
Purpose:
To compare the incidence of death, MI, stroke, embolic events, LVT, and bleeding complications at 3 months in patients with an anterior STEMI and ejection fraction less than 40% treated with ASA and clopidogrel alone versus those treated with aspirin, clopidogrel, and warfarin (triple therapy group).
Sample Size:
This is a pilot project to help establish the feasibility of conducting a full scale externally funded study. As such sample size calculations are not applicable. The primary aim of the study is to determine the safety and feasibility of conducting a large-scale trial, and this pilot project in not expected to reveal a statistically significant difference between the 2 groups.
Design/Methodology:
All patients will be randomized to either aspirin and clopidogrel alone or to triple therapy with aspirin, clopidogrel and warfarin. The randomization process will be centralized and computer generated. Patients with a clear indication for oral anticoagulation such as atrial fibrillation, LV thrombus, mechanical heart valve, or DVT/PE will not undergo randomization but will be followed as part of a registry of patients on triple therapy.
All patients will remain on the allocated therapy for 3 months at which time outcomes will be determined.
Study interventions:
Patients will be treated with either ASA and clopidogrel alone (dual therapy) or with aspirin, clopidogrel and warfarin (triple therapy) in combination for 3 months. Patients in the triple therapy arm will be bridged with intravenous unfractionated heparin, low molecular weight heparin, or fondaparinux until their INR is therapeutic, and will be followed by the thrombosis service for the duration of the study.
Ages Eligible for Study: | 18 Years to 85 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Canada, Ontario | |
Hamilton Health Sciences-Hamilton General Hopsital | |
Hamilton, Ontario, Canada, L8L 2X2 |
Principal Investigator: | Jon-David R Schwalm, MD, FRCPC | McMaster University |
Principal Investigator: | Mayraj Ahmad, MD, FRCPC | McMaster University |
Responsible Party: | McMaster University ( Dr. J-D Schwalm ) |
Study ID Numbers: | 06-281 |
Study First Received: | April 8, 2008 |
Last Updated: | April 18, 2008 |
ClinicalTrials.gov Identifier: | NCT00662467 History of Changes |
Health Authority: | Canada: Ethics Review Committee |
Myocardial Infarction Hemorrhage Thromboembolism |
Clopidogrel Aspirin Warfarin |
Anti-Inflammatory Agents Anticoagulants Heart Diseases Myocardial Ischemia Cyclooxygenase Inhibitors Vascular Diseases Fibrinolytic Agents Cardiovascular Agents Ischemia Warfarin Hemorrhage Thromboembolism |
Fibrin Modulating Agents Necrosis Aspirin Analgesics, Non-Narcotic Clopidogrel Platelet Aggregation Inhibitors Anti-Inflammatory Agents, Non-Steroidal Peripheral Nervous System Agents Analgesics Antirheumatic Agents Infarction Myocardial Infarction |
Anti-Inflammatory Agents Molecular Mechanisms of Pharmacological Action Myocardial Ischemia Hematologic Agents Physiological Effects of Drugs Fibrinolytic Agents Necrosis Fibrin Modulating Agents Pathologic Processes Aspirin Sensory System Agents Therapeutic Uses Anti-Inflammatory Agents, Non-Steroidal Cardiovascular Diseases Analgesics |
Myocardial Infarction Anticoagulants Heart Diseases Cyclooxygenase Inhibitors Vascular Diseases Enzyme Inhibitors Cardiovascular Agents Warfarin Ischemia Pharmacologic Actions Analgesics, Non-Narcotic Clopidogrel Platelet Aggregation Inhibitors Peripheral Nervous System Agents Infarction |