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Sponsored by: |
Merck |
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Information provided by: | Merck |
ClinicalTrials.gov Identifier: | NCT00757939 |
This study will assess the suitability of regional cerebral blood flow measured by dynamic arterial spin labeling as a biomarker for Alzheimer's disease
Condition | Intervention | Phase |
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Alzheimer's Disease |
Other: dASL imaging |
Phase I |
Study Type: | Interventional |
Study Design: | Diagnostic, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Bio-equivalence Study |
Official Title: | A Two-Part Cross-Sectional and Longitudinal Study to Assess Regional Cerebral Blood Flow by Dynamic Arterial Spin Labeling as an Alzheimer's Disease Biomarker as Compared to FDG-PET in Patients With Mild-to-Moderate Alzheimer's Disease and Cognitively Normal Elderly Subjects |
Estimated Enrollment: | 40 |
Study Start Date: | September 2008 |
Estimated Study Completion Date: | June 2010 |
Estimated Primary Completion Date: | March 2010 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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1: Experimental
dASL Imaging
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Other: dASL imaging
Patients will have 8 total visits including screening, assessments, and imaging over a 12 month period. Imaging will include dASL, fMRI, FDG-PET, and VBM.
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Ages Eligible for Study: | 55 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Responsible Party: | Merck & Co., Inc. ( Executive Vice President, Clinical and Quantitative Sciences ) |
Study ID Numbers: | 2008_547, 068 |
Study First Received: | September 19, 2008 |
Last Updated: | February 16, 2009 |
ClinicalTrials.gov Identifier: | NCT00757939 History of Changes |
Health Authority: | United States: Institutional Review Board |
Delirium, Dementia, Amnestic, Cognitive Disorders Mental Disorders Alzheimer Disease Central Nervous System Diseases Neurodegenerative Diseases |
Brain Diseases Dementia Cognition Disorders Delirium |
Delirium, Dementia, Amnestic, Cognitive Disorders Mental Disorders Nervous System Diseases Alzheimer Disease Central Nervous System Diseases |
Neurodegenerative Diseases Tauopathies Brain Diseases Dementia |