Study of Stored Tumor Samples in Young Patients With Brain Tumors - Full Text View

Sponsors and Collaborators:	St. Jude Children's Research Hospital National Cancer Institute (NCI)
Information provided by:	National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:	NCT00897286

Purpose

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This laboratory study is looking at stored tumor samples in young patients with brain tumors.

Condition	Intervention
Brain and Central Nervous System Tumors	Genetic: comparative genomic hybridization Genetic: fluorescence in situ hybridization Genetic: microarray analysis Genetic: polymerase chain reaction Genetic: polymorphism analysis Genetic: protein expression analysis Genetic: western blotting Other: laboratory biomarker analysis

Study Type:	Observational
Official Title:	MOLECULAR AND HISTOPATHOLOGIC CHARACTERIZATION OF ATYPICAL TERATOID RHABDOID TUMORS, CHOROID PLEXUS CARCINOMAS, EPENDYMOMAS AND MEDULLOBLASTOMA/PNET OF THE PEDIATRIC CNS

Resource links provided by NLM:

MedlinePlus related topics: Brain Cancer Cancer Childhood Brain Tumors

U.S. FDA Resources

Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:

Relationship between molecular abnormalities and tumor histologic and clinical characteristics [ Designated as safety issue: No ]

Study Start Date:	November 2004
Estimated Primary Completion Date:	November 2014 (Final data collection date for primary outcome measure)

Detailed Description:

OBJECTIVES:

To identify molecular abnormalities within CNS atypical teratoid rhabdoid tumors (ATRT), choroid plexus carcinoma (CPC), and ependymoma in prospectively treated pediatric patients.
To define the relationship between these abnormalities and tumor histologic and clinical characteristics.

OUTLINE: Previously collected tissue samples are collected and processed for pathological classification and preparation for tissue microarray. Gene expression profiles for tumor samples are constructed using Affymetrix microarray analysis, comparative genomic hybridization array analysis, and single nucleotide polymorphism array analysis. Polymerase chain reaction is used to perform gene sequence analysis to identify potential oncogenes and tumor suppressor genes in the brain tumor. The expression of cell signal proteins is analyzed using standard western blotting. Fixed tumor material is analyzed using fluorescence in situ hybridization to determine deletions or amplifications. Cell culture assays are used for growth and differentiation analysis of cultured cells, molecular characterization of cultured cells, cell signal analysis, and orthotopic xenograft analysis.

Eligibility

Ages Eligible for Study:	up to 21 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

DISEASE CHARACTERISTICS:

Diagnosis of 1 of the following diseases documented by the local neuropathologist:
- Atypical teratoid rhabdoid tumor
- Choroid plexus carcinoma
- Medulloblastoma/supratentorial primitive neuroectodermal tumor
- Ependymoma of the CNS
Disease may be primary, progressive, or relapsed
Must be enrolled in the current version of the institution's banking protocol

PATIENT CHARACTERISTICS:

Not specified

PRIOR CONCURRENT THERAPY:

See Disease Characteristics

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00897286

Locations

United States, Pennsylvania
Children's Hospital of Philadelphia	Recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Contact Person 215-590-3025
United States, Tennessee
St. Jude Children's Research Hospital	Recruiting
Memphis, Tennessee, United States, 38105
Contact: Clinical Trials Office - St. Jude Children's Research Hospital 901-595-4644

Sponsors and Collaborators

St. Jude Children's Research Hospital

National Cancer Institute (NCI)

Investigators

Principal Investigator:	Amar Gajjar, MD	St. Jude Children's Research Hospital
Principal Investigator:	Richard J. Gilbertson, MD, PhD	St. Jude Children's Research Hospital

More Information

Additional Information:

Clinical trial summary from the National Cancer Institute's PDQ® database This link exits the ClinicalTrials.gov site

No publications provided

Study ID Numbers:	CDR0000593406, SJCRH-NBTP01
Study First Received:	May 9, 2009
Last Updated:	June 9, 2009
ClinicalTrials.gov Identifier:	NCT00897286 History of Changes
Health Authority:	Unspecified

Keywords provided by National Cancer Institute (NCI):

childhood atypical teratoid/rhabdoid tumor
childhood choroid plexus tumor
childhood medulloblastoma
recurrent childhood medulloblastoma
childhood infratentorial ependymoma

childhood supratentorial ependymoma
recurrent childhood ependymoma
recurrent childhood supratentorial primitive neuroectodermal tumor
untreated childhood supratentorial primitive neuroectodermal tumor

Study placed in the following topic categories:

Choroid Plexus Neoplasms
Neuroectodermal Tumors, Primitive
Rhabdoid Tumor
Central Nervous System Neoplasms
Ependymoma
Recurrence
Carcinoma
Brain Neoplasms

Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Medulloblastoma
Neuroepithelioma
Glioma
Nervous System Neoplasms
Neoplasms, Glandular and Epithelial

Additional relevant MeSH terms:

Neoplasms by Histologic Type
Neuroectodermal Tumors, Primitive
Nervous System Diseases
Neoplasms, Nerve Tissue
Central Nervous System Neoplasms
Neuroectodermal Tumors
Neoplasms

Neoplasms by Site
Neoplasms, Germ Cell and Embryonal
Medulloblastoma
Glioma
Neoplasms, Neuroepithelial
Nervous System Neoplasms
Neoplasms, Glandular and Epithelial

ClinicalTrials.gov processed this record on September 10, 2009