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Sponsored by: |
AstraZeneca |
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Information provided by: | AstraZeneca |
ClinicalTrials.gov Identifier: | NCT00242346 |
The purpose of this study is to assess the effects of high doses of candesartan cilexetil and also to assess which dose (16mg, 64mg, 128mg) is the most optimal for the maximum reduction of proteinuria.
Condition | Intervention | Phase |
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Proteinuria |
Drug: candesartan cilexetil |
Phase III |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Dose Comparison, Parallel Assignment, Safety/Efficacy Study |
Official Title: | A Double-Blind, Randomised, Dose Ranging, Multi-Centre, Phase IIIb Study to Evaluate the Efficacy and Safety of High Doses of Candesartan Cilexetil (Atacand®) on the Reduction of Proteinuria in the Treatment of Subjects With Hypertension and Moderate to Severe Proteinuria |
Estimated Enrollment: | 270 |
Study Start Date: | April 2003 |
Study Completion Date: | December 2006 |
Ages Eligible for Study: | 18 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Canada, Alberta | |
Research Site | |
Calgary, Alberta, Canada | |
Research Site | |
Edmonton, Alberta, Canada | |
Canada, British Columbia | |
Research Site | |
Kelowna, British Columbia, Canada | |
Research Site | |
Vancouver, British Columbia, Canada | |
Canada, Manitoba | |
Research Site | |
Winnipeg, Manitoba, Canada | |
Canada, Newfoundland and Labrador | |
Research Site | |
St. John, Newfoundland and Labrador, Canada | |
Canada, Nova Scotia | |
Research Site | |
Halifax, Nova Scotia, Canada | |
Canada, Ontario | |
Research Site | |
Courtice, Ontario, Canada | |
Research Site | |
Kitchener, Ontario, Canada | |
Research Site | |
London, Ontario, Canada | |
Research Site | |
Oshawa, Ontario, Canada | |
Research Site | |
Oakville, Ontario, Canada | |
Research Site | |
Mississauga, Ontario, Canada | |
Research Site | |
Richmond Hill, Ontario, Canada | |
Research Site | |
Scarborough, Ontario, Canada | |
Research Site | |
Sudbury, Ontario, Canada | |
Research Site | |
Thunder Bay, Ontario, Canada | |
Research Site | |
Weston, Ontario, Canada | |
Research Site | |
Toronto, Ontario, Canada | |
Research Site | |
Timmins, Ontario, Canada | |
Canada, Quebec | |
Research Site | |
Greenfield Park, Quebec, Canada | |
Research Site | |
Laval, Quebec, Canada | |
Research Site | |
Montreal, Quebec, Canada | |
Research Site | |
Ste-Foy, Quebec, Canada | |
Research Site | |
Quebec City, Quebec, Canada | |
Canada, Saskatchewan | |
Research Site | |
Saskatoon, Saskatchewan, Canada |
Study Director: | Kazi Borkowski, PhD | AstraZeneca |
Principal Investigator: | Norman MuirHead, MD | London HSC |
Principal Investigator: | Ellen Burgess, MD | Foothills Medical Center |
Study ID Numbers: | D2452L00006, DC-AHS-0006, SMART |
Study First Received: | October 18, 2005 |
Last Updated: | December 17, 2007 |
ClinicalTrials.gov Identifier: | NCT00242346 History of Changes |
Health Authority: | Canada: Health Canada |
Hypertension |
Angiotensin II Type 1 Receptor Blockers Candesartan cilexetil Signs and Symptoms Proteinuria Urologic Diseases Urination Disorders |
Candesartan Cardiovascular Agents Angiotensin II Antihypertensive Agents Hypertension |
Molecular Mechanisms of Pharmacological Action Urination Disorders Cardiovascular Agents Antihypertensive Agents Pharmacologic Actions Candesartan cilexetil Angiotensin II Type 1 Receptor Blockers |
Urological Manifestations Signs and Symptoms Proteinuria Urologic Diseases Therapeutic Uses Candesartan |