Prevalence of Delirium in Patients Undergoing Cardiac Surgery

This study is currently recruiting participants.

Verified by University Health Network, Toronto, September 2006

First Received: October 18, 2005 Last Updated: October 11, 2006 History of Changes

Sponsored by:	University Health Network, Toronto
Information provided by:	University Health Network, Toronto
ClinicalTrials.gov Identifier:	NCT00242151

Purpose

The objective of this study is to determine prevalence of postoperative delirium and confusion in patients undergoing cardiac surgery. This proposal is a pilot study designed to evaluate effect of cardiac surgery on prevalence of delirium and confusion. The primary aim is to evaluate prevalence of delirium and confusion in patients undergoing cardiac surgery and to determine risk factors for this condition. A secondary aim is to evaluate organic brain injury by early postoperative diffusion weighted magnetic resonance imaging (DW-MRI) in patients who develop delirium and confusion. The hypothesis to be tested is that patients with postoperative delirium and confusion have high incidence of organic brain injury as detected by DW-MRI.

Condition
Heart Disease

Study Type:	Observational
Study Design:	Psychosocial, Longitudinal, Defined Population, Prospective Study
Official Title:	Prevalence of Delirium in Patients Undergoing Cardiac Surgery

Resource links provided by NLM:

MedlinePlus related topics: Heart Diseases Heart Surgery MRI Scans Surgery Traumatic Brain Injury

U.S. FDA Resources

Further study details as provided by University Health Network, Toronto:

Estimated Enrollment:

100

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion criteria:

All patients undergoing cardiac surgery in our institute in 2 year period
Signed informed consent

Exclusion criteria:

Past history of transient ischemic attacks, stroke, symptomatic carotid artery disease.
Past history of psychiatric disorders
History of alcohol and drug abuse
History of severe kidney or liver disease (creatinine >2.5mg/dL and bilirubin > 2mg/dL)
Known contraindications to MRI

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00242151

Contacts

Contact: Jo A Carroll, RN

416-340-4800 ext 3243

jo.carroll@uhn.on.ca

Locations

Canada, Ontario
Toronto General Hospital, University Health Network	Recruiting
Toronto, Ontario, Canada, M5G 2C4
Contact: Jo A Carroll, RN 416-340-4800 ext 3243 jo.carroll@uhn.on.ca
Sub-Investigator: George N Djaiani, MD
Sub-Investigator: Susan Abbey, MD
Sub-Investigator: Jacek M Karski, MD

Sponsors and Collaborators

University Health Network, Toronto

Investigators

Principal Investigator:

Rita Katznelson, MD

Toronto General Hospital, University Health Network

More Information

No publications provided

Study ID Numbers:	UHN REB 05-0223-AE
Study First Received:	October 18, 2005
Last Updated:	October 11, 2006
ClinicalTrials.gov Identifier:	NCT00242151 History of Changes
Health Authority:	Canada: Ethics Review Committee

Keywords provided by University Health Network, Toronto:

Delirium, Confusion, Cardiac Surgery, Organic Brain Injury, Diffusion Weighted Magnetic Resonance Imaging (DW-MRI)

Study placed in the following topic categories:

Signs and Symptoms
Delirium, Dementia, Amnestic, Cognitive Disorders
Heart Diseases
Mental Disorders
Neurologic Manifestations
Confusion

Dementia
Brain Injuries
Neurobehavioral Manifestations
Cognition Disorders
Delirium

Additional relevant MeSH terms:

Signs and Symptoms
Delirium, Dementia, Amnestic, Cognitive Disorders
Heart Diseases
Mental Disorders
Nervous System Diseases

Neurologic Manifestations
Cardiovascular Diseases
Confusion
Neurobehavioral Manifestations
Delirium

ClinicalTrials.gov processed this record on September 10, 2009