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Sponsored by: |
University of Heidelberg |
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Information provided by: | University of Heidelberg |
ClinicalTrials.gov Identifier: | NCT00176085 |
A study on the fate and elimination of 11-Nor-9-carboxy-9-tetrahydrocannabinol was up to now not conducted, except of one single experiment in which (lacking) psychopharmacologi-cal activity was tested after intravenous infusion of 20 mg in a human individual. In this study, however, the authors did not trace the above questions due to analytical and methodological deficits. Aim of the study is to determine the pharmacokinetics of THCCOOH and THCCOOH-Glu after intravenous ad-ministration of 5 mg THCCOOH in healthy individuals
Study Type: | Observational |
Study Design: | Screening, Cross-Sectional, Defined Population, Prospective Study |
Official Title: | Pharmacokinetics of 11-Nor-9-Carboxy-D9-Tetrahydrocannabinol (THCCOOH) and Its Acyl-Glucuronide (THCCOOH-GLu) After Intravenous Administration of THCCOOH in Healthy Human Subjects |
Estimated Enrollment: | 10 |
Study Start Date: | October 2004 |
Study Completion Date: | March 2005 |
To determine the pharmacokinetics of THCCOOH after intravenous administration of THCCOOH (5 mg) and its formed glucuronide in healthy individuals in order to improve the possibilities for the assessment of unfitness to drive. For these purposes the following criteria will be studied: THCCOOH
Ages Eligible for Study: | 18 Years to 50 Years |
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Germany | |
Clinical Research Center, Department of Internal Medicine VI | |
Heidelberg, Germany, 69120 |
Principal Investigator: | Gerd Mikus, MD BSc | Department of Internal Medicine VI |
Study ID Numbers: | K107 |
Study First Received: | September 12, 2005 |
Last Updated: | April 16, 2007 |
ClinicalTrials.gov Identifier: | NCT00176085 History of Changes |
Health Authority: | Germany: Federal Institute for Drugs and Medical Devices |
Tetrahydrocannabinol Glutamic Acid Healthy |