Home
Search
Study Topics
Glossary
|
|
|
|
|
Sponsored by: |
Merck |
---|---|
Information provided by: | Merck |
ClinicalTrials.gov Identifier: | NCT00902161 |
This study will assess the effect of combined treatment with MK0893 plus propranolol versus placebo plus propranolol on hypoglycemia.
Condition | Intervention | Phase |
---|---|---|
Type 2 Diabetes Mellitus |
Drug: MK0893 Drug: Comparator: placebo Drug: Comparator: propranolol |
Phase I |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double Blind (Subject, Investigator), Placebo Control, Crossover Assignment, Safety Study |
Official Title: | A Double-Blind, Randomized, Placebo-Controlled, Single-Dose Crossover Study to Assess the Safety and Tolerability of MK0893 Coadministered With Propranolol Hydrochloride in Patients With Type 2 Diabetes |
Estimated Enrollment: | 18 |
Study Start Date: | April 2009 |
Estimated Study Completion Date: | January 2010 |
Estimated Primary Completion Date: | August 2009 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
---|---|
1: Experimental
MK0893
|
Drug: MK0893
Single dose of MK0893 1000 mg (ten 100 mg tablets)
Drug: Comparator: propranolol
Propranolol tablets titrated up to 80 mg three times daily over a four week period. Total treatment will be approximately 7 weeks.
|
2: Placebo Comparator
Placebo
|
Drug: Comparator: placebo
Single dose of placebo to MK0893
Drug: Comparator: propranolol
Propranolol tablets titrated up to 80 mg three times daily over a four week period. Total treatment will be approximately 7 weeks.
|
Ages Eligible for Study: | 18 Years to 60 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Toll Free Number | 1-888-577-8839 |
United States, California | |
Call for Information | Recruiting |
Chula Vista, California, United States, 91911 |
Study Director: | Medical Monitor | Merck |
Responsible Party: | Merck & Co., Inc. ( Executive Vice President, Clinical and Quantitative Sciences ) |
Study ID Numbers: | 2009_592, MK0893-019 |
Study First Received: | May 13, 2009 |
Last Updated: | September 2, 2009 |
ClinicalTrials.gov Identifier: | NCT00902161 History of Changes |
Health Authority: | United States: Food and Drug Administration |
Vasodilator Agents Neurotransmitter Agents Metabolic Diseases Adrenergic Agents Diabetes Mellitus Endocrine System Diseases Cardiovascular Agents Antihypertensive Agents |
Propranolol Diabetes Mellitus, Type 2 Adrenergic beta-Antagonists Adrenergic Antagonists Endocrinopathy Anti-Arrhythmia Agents Glucose Metabolism Disorders Metabolic Disorder |
Vasodilator Agents Neurotransmitter Agents Metabolic Diseases Molecular Mechanisms of Pharmacological Action Adrenergic Agents Physiological Effects of Drugs Diabetes Mellitus Endocrine System Diseases Cardiovascular Agents |
Antihypertensive Agents Pharmacologic Actions Propranolol Therapeutic Uses Diabetes Mellitus, Type 2 Adrenergic beta-Antagonists Adrenergic Antagonists Anti-Arrhythmia Agents Glucose Metabolism Disorders |