Obesity and the Initiation of Knee Osteoarthritis - Full Text View

Sponsored by:	Department of Veterans Affairs
Information provided by:	Department of Veterans Affairs
ClinicalTrials.gov Identifier:	NCT00856739

Purpose

Healthy adults aged 20-60 of varying weights will participate in this minimally invasive study. There is one 4-hour appointment for which subjects are paid $120. The tests involve: 1 tube blood draw, 1 gait test (motion capture) and 1 MR of both knees.

Condition
Osteochondritis

Study Type:	Observational
Study Design:	Ecologic or Community
Official Title:	Obesity and Initiation of Osteoarthritis

Resource links provided by NLM:

MedlinePlus related topics: Obesity Osteoarthritis

U.S. FDA Resources

Further study details as provided by Department of Veterans Affairs:

Primary Outcome Measures:

Knee MR cartilage wear, Gait knee adduction moment, COMP value in blood. [ Time Frame: baseline or first and only visit. ] [ Designated as safety issue: No ]

Biospecimen Retention: Samples Without DNA

Biospecimen Description:

One tube of blood identified with a unique number.

Estimated Enrollment:	200
Study Start Date:	March 2009
Estimated Study Completion Date:	March 2012
Estimated Primary Completion Date:	March 2012 (Final data collection date for primary outcome measure)

Groups/Cohorts
1

Detailed Description:

The tests will be done at the VA and Stanford and a re not dangerous or painful. They are designed to help us learn more about the relationship of excess weight on cartilage degradation by testing a biomarker in blood.

Gait testing involves walking in a lab that is about 20 meters long about 20 times. MR involves lying in a tube for less than 1 hour.

Eligibility

Ages Eligible for Study:	20 Years to 60 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

Healthy adults aged 20-60, of varying weights.

Criteria

Inclusion Criteria:

Healthy Adults aged 20-60 who have no history of LE surgery and are able to walk 30 minutes and have MR.

Exclusion Criteria:

Adults who have had LE surgery, cannot walk 30 minutes and/or cannot tolerate MR.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00856739

Locations

United States, California
VA Palo Alto Health Care System
Palo Alto, California, United States, 94304-1290

Sponsors and Collaborators

Department of Veterans Affairs

Investigators

Principal Investigator:

Thomas P. Andriacchi, PhD

VA Palo Alto Health Care System

More Information

No publications provided

Responsible Party:	Department of Veterans Affairs ( Andriacchi, Thomas - Principal Investigator )
Study ID Numbers:	A6650R, 7924, 15723
Study First Received:	March 5, 2009
Last Updated:	March 5, 2009
ClinicalTrials.gov Identifier:	NCT00856739 History of Changes
Health Authority:	United States: Federal Government

Keywords provided by Department of Veterans Affairs:

obesity
arthritis

Study placed in the following topic categories:

Obesity
Osteoarthritis
Joint Diseases
Overweight
Rheumatic Diseases
Bone Diseases
Body Weight
Osteoarthritis, Knee

Osteochondritis
Signs and Symptoms
Musculoskeletal Diseases
Arthritis
Connective Tissue Diseases
Cartilage Diseases
Nutrition Disorders
Overnutrition

Additional relevant MeSH terms:

Obesity
Osteoarthritis
Joint Diseases
Overweight
Rheumatic Diseases
Bone Diseases
Body Weight
Osteochondritis

Osteoarthritis, Knee
Signs and Symptoms
Musculoskeletal Diseases
Arthritis
Connective Tissue Diseases
Cartilage Diseases
Nutrition Disorders
Overnutrition

ClinicalTrials.gov processed this record on September 10, 2009