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Sponsored by: |
QLT Inc |
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Information provided by: | QLT Inc |
ClinicalTrials.gov Identifier: | NCT00042302 |
To determine whether tariquidar + combined first-line chemotherapy of paclitaxel/carboplatin in patients with Stage IIIb/IV NSCLC will, with an acceptable safety profile, significantly improve overall survival compared with placebo + paclitaxel/carboplatin. To compare the effects of tariquidar/paclitaxel/carboplatin with placebo/paclitaxel/carboplatin on tumor response, time to disease progression, performance status, symptom progression, and quality of life in patients with Stage IIIb/IV NSCLC.
Condition | Intervention | Phase |
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Stage IIIB Non-Small Cell Lung Cancer Stage IV Non-Small Cell Lung Cancer |
Procedure: Chemotherapy Drug: tariquidar + paclitaxel/carboplatin Drug: placebo + paclitaxel/carboplatin |
Phase III |
Study Type: | Interventional |
Study Design: | Randomized, Double-Blind, Placebo Control |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | TQD LUNG 001 |
Study First Received: | July 26, 2002 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00042302 History of Changes |
Health Authority: | United States: Food and Drug Administration |
Thoracic Neoplasms Carboplatin Antimitotic Agents Carcinoma Respiratory Tract Diseases Lung Neoplasms Paclitaxel |
Lung Diseases Tubulin Modulators Non-small Cell Lung Cancer Carcinoma, Non-Small-Cell Lung Antineoplastic Agents, Phytogenic Neoplasms, Glandular and Epithelial |
Thoracic Neoplasms Respiratory Tract Neoplasms Neoplasms by Histologic Type Molecular Mechanisms of Pharmacological Action Antineoplastic Agents Mitosis Modulators Antimitotic Agents Carboplatin Pharmacologic Actions Carcinoma Neoplasms |
Neoplasms by Site Respiratory Tract Diseases Lung Neoplasms Paclitaxel Therapeutic Uses Lung Diseases Tubulin Modulators Antineoplastic Agents, Phytogenic Carcinoma, Non-Small-Cell Lung Neoplasms, Glandular and Epithelial |