Inclusion Criteria:

1. Age 18 years or more and less than 60 years

2. With:

   A morphologically proven diagnosis of AML according to the WHO classification, cytogenetically (standard karyotype, FISH-MLL) and molecularly (FLT3, CEBPA, NMP1) defined.

3. ECOG performance status 0 to 2.

4. Have adequate renal and hepatic function as indicated by the following laboratory values:

   • Creatinine clearance (calculated by the cockcroft and Gault method) ≥ 40mL/min;
   • AST and ALT < or = 2.5N; total bilirubin < or = 2N (unless related to the underlying disease).
5. Cardiac function determined by radionuclide or echography within normal limits.
6. Women of child-bearing potential (i.e. women who are pre-menopausal or not surgically sterile) must use acceptable contraceptive methods, and must have a negative serum or urine pregnancy test within 2 weeks prior the beginning treatment on this trial.
7. Must be able and willing to give written informed consent.
8. The subject must be covered by a social security system.

Exclusion Criteria:

1. Patients with AML with favorable risk cytogenetics: M3-AML; CBF-AML including t(8:21), inv(16), or t(16;16) AML.
2. Ph-positive AML.
3. AML following diagnosed myeloproliferation or patient with prior history of MDS known for more than 3 months
4. Prior treatment with chemotherapy or radiotherapy for another tumor.
5. Prior tumor, if not stable for at least two years, except in-situ carcinoma and skin carcinoma
6. Compromised organ function judged to be lifethreatening by the Investigator.
7. Positive serology for HIV, HBV and HBC (except post vaccination)
8. Uncontrolled active infection of any kind or bleeding. Patients with infections who are under active treatment with antibiotics and whose infections are controlled may be entered to the study.
9. Other active malignancy.
10. Patients concurrently receiving any other standard or investigational treatment for their leukemia, with the exception of hydroxyurea.