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Sponsored by: |
University Hospital Muenster |
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Information provided by: | University Hospital Muenster |
ClinicalTrials.gov Identifier: | NCT00126087 |
The investigators plan to improve the learning of motor skills by pharmacological means (dopamine), and by noninvasive brain stimulation. They will study both healthy subjects and chronic stroke patients. In addition, they want to study the mechanisms of enhanced learning, on the molecular and the systems level.
Condition | Intervention | Phase |
---|---|---|
Stroke |
Drug: dopamine |
Phase IV |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Efficacy Study |
Official Title: | Potentiation of Procedural Motor Learning by Pharmacological Neuromodulation and Transcranial Direct Current Stimulation in Health and Disease |
Estimated Enrollment: | 40 |
Study Start Date: | July 2005 |
Estimated Study Completion Date: | June 2008 |
Adaptive behavior requires procedural motor learning, i.e. the acquisition of motor skills. Procedural learning is particularly critical in the rehabilitation of chronic motor deficits after stroke. A potent modulator of motor function and learning is found in the endogenous dopaminergic system. The investigator's own work could demonstrate that formation of an elementary motor memory, which constitutes the first step in acquiring more complex motor skills, can be enhanced in both healthy subjects and chronic stroke patients by pre-medication with levodopa. The aim of the present proposal is to:
The effect of levodopa +/- tDCS on procedural motor learning and cortical excitability will be studied in healthy volunteers and stroke patients. Then the investigator plans to delineate the underlying mechanisms of this effect by exploring N-methyl-D-asparate (NMDA) receptor-dependency of levodopa-enhanced learning and changes in activation and connectivity (using functional magnetic resonance imaging) in the respective neural networks resulting from the interaction of learning and dopaminergic neuromodulation.
Ages Eligible for Study: | 18 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Healthy Volunteers:
Stroke Patients:
Exclusion Criteria:
Healthy Volunteers and Stroke Patients:
Contact: Agnes Flöel, MD | +49 251 83 ext 49970 | floeel@uni-muenster.de |
Contact: Caterina Breitenstein, PhD | +49 251 83 ext 49969 | breitens@uni-muenster.de |
Germany, Nordrhein-Westfalen | |
University of Münster, Department of Neurology | Recruiting |
Münster, Nordrhein-Westfalen, Germany, 48129 | |
Contact: Kreuznacht +49-251-83-55967 kreuznac@klinikum.uni-muenster.de | |
Principal Investigator: Agnes Flöel, MD |
Principal Investigator: | Agnes Flöel, MD | University of Münster, Department of Neurology, Germany |
Study ID Numbers: | Motor-Neuromod_01 |
Study First Received: | July 31, 2005 |
Last Updated: | April 19, 2007 |
ClinicalTrials.gov Identifier: | NCT00126087 History of Changes |
Health Authority: | Germany: Federal Institute for Drugs and Medical Devices |
dopamine NMDA receptor brain imaging neuroplasticity |
learning transcranial direct current stimulation rehabilitation aging |
Neurotransmitter Agents Dopamine Cerebral Infarction Stroke |
Dopamine Agents Peripheral Nervous System Agents Cardiovascular Agents |
Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Cardiotonic Agents Sympathomimetics Physiological Effects of Drugs Cardiovascular Agents Protective Agents |
Pharmacologic Actions Dopamine Autonomic Agents Therapeutic Uses Dopamine Agents Peripheral Nervous System Agents |