NIDA Research Monograph, Number 175 [Printed in 1998]
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Table of Contents
Preface-----1
Betty Tai, Charles V. Grudzinskas, Nora Chiang, and
Peter Bridge
Goals and Rationale for Pharmacotherapeutic Approach in Treating Cocaine Dependence: Insights From Basic and
Clinical Research-----5
Mary Jeanne Kreek
Overview of Potential Treatment Medications for Cocaine
Dependence-----36
Elinore F. McCance
Methodologic Recommendations for Cocaine Abuse Clinical
Trials: A Clinician-Researcher's Perspective-----73
Edward V. Nunes
Management of Clinical Trials With New Medications for
Cocaine Dependence and Abuse-----96
Ari Kiev
Outcome Measurement Considerations: Pharmacological
Treatments for Substance Abuse-----118
Karla Moras
Variability in Treatment-Seeking Cocaine Abusers: Implications
for Clinical Pharmacotherapy Trials-----137
Kathleen M. Carroll, Charla Nich, and Bruce J. Rounsaville
Baseline Assessment, Study Entry, and Stabilization:
Double-Blind Clinical Trials in Drug Dependence-----158
John Grabowski, Gila Arnoni, Ronith Elk, Howard Rhoades,
and Joy Schmitz
The Addiction Severity Index in Clinical Efficacy Trials of
Medications for Cocaine Dependence-----182
John S. Cacciola, Arthur I. Alterman, Charles P. O'Brien,
and A. Thomas McLellan
Cognitive-Neuromotor Assessment of Substance Abuse:
Focus on Issues Related to Cocaine Abuse Treatment-----192
E.H. Ellinwood, Jr. and T.H. Lee
Treatment Effectiveness Score as an Outcome Measure in
Clinical Trials-----208
Walter Ling, Steven Shoptaw, Donald Wesson, Richard A.
Rawson, Margaret Compton, and C. James Klett
Pharmacokinetics of Cocaine: Considerations When Assessing
Cocaine Use by Urinalysis-----221
Reese T. Jones
Quantitative Urine Levels of Cocaine and Other Substances of Abuse-----235
Jeffery N. Wilkins
Use of Quantitative Urinalysis in Monitoring Cocaine Use-----253
Kenzie L. Preston, Kenneth Silverman, Charles R. Schuster,
and Edward J. Cone
Is Quantitative Urinalysis More Sensitive?-----265
Shou-Hua Li, Nora Chiang, Betty Tai, Charles K.
Marschke, and Richard L. Hawks
Comparison of Immunoassays for Semiquantitative Measurement
of Benzoylecgonine in Urine-----287
Rodger L. Foltz, Christine Botelho, Scott A. Reuschel,
David J. Kuntz, David E. Moody, and Gloria M. Bristow
TAppendix I: Workshop Summary Outcome Measures and
Success Criteria-----303
Betty Tai
Appendix II: Workshop Summary Clinical Decision Tree for
Cocaine Addiction Pharmacotherapy-----312
Betty Tai, Charles V. Grudzinskas, Peter Bridge, and
Nora Chiang
Ordering Information-----318
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