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Opioid Peptides: Medicinal Chemistry |
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NIDA Research Monograph, Number 69 [Printed in 1986]This monograph is not available by chapter. The Table of Contents (below) is shown to assist in locating information prior to downloading the monograph.Download Monograph69.pdf - Opioid Peptides: Medicinal Chemistry (3.7 MB) Table of Contents Foreword-----v Introduction-----1 Frontiers of Research in the Medicinal Chemistry and Molecular Pharmacology of Opioid Peptides-----3 Synthesis of Opioid Peptide Analogs-----21 Structure-Activity Relationships of Opioid Peptides-----42 Design Principles: Enkephalins With Predictable Mu/Delta Receptor Specificity-----65 Structure-Activity Relationship and Pharmacology of the Highly Selective ยต-Opioid Agonist, Morphiceptin-----101 Dermorphin: Autonomic Pharmacology and Structure-Activity Relationships-----112 Design of Conformationally Constrained Cyclic Peptides With High Delta and Mu Opioid Receptor Specificities-----128 Dehydro and Cyclopropyl Amino Acids and Peptides-----148 Affinity Labels as Probes for Opioid Receptor Types and Subtypes-----157 Peptide Conformation and Biological Activity: A General Review with Examples of Approaches Relevant to Opioid Peptide Function-----169 Opioid Peptides: Analysis of Specificity and Multiple Binding Modes Through Computer-Aided Drug Design and Structure-Activity Studies-----204 Mechanistic Structure-Activity Studies of Peptide and Nonpeptide Flexible Opioids: An Interdisciplinary Approach-----231 Conformations of Opioid Peptides as Determined by Nuclear Magnetic Resonance and Related Spectroscopies-----266 Conformational Analysis of Opioid Peptides and the Use of Conformational Restriction in the Design of Selective Analogs-----291 Stereochemically Constrained Enkephalin Analogs Containing X-Aminoisobutyric Acid and 1-Amino-Cyclopentane-l-Carbolylic Acid-----312 Enkephalin Conformation in Solution: A Perspective From Vibrational Spectroscopic Studies-----332 Conformational Features of the Opioid Peptides in the Solid State: A Review of X-Ray Crystallographic Research-----351 The Search for Nonaddicting Strong Analgesics: Hopes and Frustrations-----364 |
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