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Discovery of Novel Opioid Medications |
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![]() NIDA Research Monograph, Number 147 [Printed in 1995]![]() Download Monograph147.pdf - Discovery of Novel Opioid Medications (2.1 MB) Table of Contents Introduction-----v Targeting Drugs to the Brain by Sequential Metabolism-----1 Action of Opioid Drugs on the Brain-Reward System-----33 Drugs That Modify Opioid Tolerance, Physical Dependence, and Abstinence Symptoms: Preclinical and Clinical Studies-----53 Future Directions in the Pharmacological Management of Hyperalgesic and Allodynic Pain States: The NMDA Receptor-----84 Dual Inhibitors of Enkephalin-Degrading Enzymes (Neutral Endopeptidase 24.11 and Aminopeptidase N) as Potential New Medications in the Management of Pain and Opioid Addiction-----104 Enhanced N-Methyl-D-Aspartate (NMDA)-Induced Activity Following Morphine: Sensitivity to Sigma and PCP Ligands-----146 Dynorphin A: A Rectifying Peptide-----161 Inhibitors of Nitric Oxide Synthase and the Opioid Withdrawal Syndrome-----170 Nitric Oxide and Opioid Tolerance-----182 Methoclocinnamox: A ยต Partial Agonist With Pharmacotherapeutic Potential for Heroin Abuse-----195 ACEA-1011, a Novel NMDA Receptor/Glycine Site Antagonist, Produces Antinociception but Not Tolerance in the Formalin Test in Mice-----220 Etorphine Elicits Unique Inhibitory-Agonist and Excitatory-Antagonist
Actions at Opioid Receptors on Sensory Neurons: New Rationale for
Improved Clinical Analgesia and Treatment of Opiate Addiction-----234 The Association of Neuropathic Pain, Morphine Tolerance and Dependence, and the Translocation of Protein Kinase C-----269 |
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