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Statistical Issues in Clinical Trials for Treatment of Opiate Dependence |
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![]() NIDA Research Monograph, Number 128 [Printed in 1992]![]() Download Monograph128.pdf - Statistical Issues in Clinical Trials for Treatment of Opiate Dependence (1.4 MB) Table of Contents Introduction-----1 Drug Dependence (Addiction) and Its Treatment-----6 Background and Design of a Controlled Clinical Trial (ARC 090) for the Treatment of Opioid Dependence-----14 Clinical Endpoints: Discussion Session-----25 Design of Clinical Trials for Treatment of Opiate Dependence: What Is Missing?-----29 Comments-----37 Rejoinder-----42 Summary of Discussion-----44 Efficacy of Urinalysis in Monitoring Heroin and Cocaine Abuse Patterns: Implications in Clinical Trials for Treatment of Drug Dependence-----46 Comments-----59 Summary of Discussion-----62 Open/Panel Discussion: Design Issues-----64 A Bayesian Nonparametric Approach to Analysis of Treatment for
Drug Dependence Data-----70 Three Estimators of the Probability of Opiate Use From Incomplete Data-----82 Summary of Discussion-----95 Issues in the Analysis of Clinical Trials for Opiate Dependence-----97 Summary of Discussion-----114 Analysis of Clinical Trials for Treatment of Opiate Dependence: What
Are the Possibilities?-----116 Summary of Discussion-----135 Toward a Dynamic Analysis of Disease-State Transition Monitored by
Serial Clinical Laboratory Tests-----137 Summary of Discussion-----158 A Markov Model for NIDA Data on Treatment of Opiate Dependence-----160 Summary of Discussion-----168 Open/Panel Discussion: Analysis Issues-----170 Open/Panel Discussion: General Issues-----176 List of Participants-----182 List of NIDA Research Monographs-----186 |
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