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Sponsors and Collaborators: |
University of Manitoba Canola Council of Canada Flax Canada 2015 Agri-Food Research and Development Initiative |
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Information provided by: | University of Manitoba |
ClinicalTrials.gov Identifier: | NCT00927199 |
The purpose of this study is to assess the efficacy of high-oleic canola oil and a high-oleic canola/flaxseed oil blend as compared to a typical Western diet on plasma lipids, fatty acid profiles, and risk factors associated with cardiovascular disease in hypercholesterolemic patients. Furthermore, the metabolism of dietary oleic acid and alpha-linolenic acid contained in high-oleic canola oil and flaxseed oil will be investigated.
Condition | Intervention | Phase |
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Cardiovascular Disease |
Dietary Supplement: High-Oleic Canola Oil Dietary Supplement: High-Oleic Canola/Flaxseed Oil Blend Dietary Supplement: Western Dietary Control |
Phase II |
Study Type: | Interventional |
Study Design: | Prevention, Randomized, Single Blind (Subject), Active Control, Crossover Assignment, Efficacy Study |
Official Title: | Efficacy of Consumption of High-Oleic Canola and Flaxseed Oils in the Management of Hypercholesterolemia and Other Cardiovascular Risk Factors |
Enrollment: | 36 |
Study Start Date: | September 2007 |
Study Completion Date: | June 2008 |
Primary Completion Date: | June 2008 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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High-Oleic Canola Oil: Experimental |
Dietary Supplement: High-Oleic Canola Oil
Diets contained 35% energy as fat; of which 70% was provided by high-oleic canola oil (high in monounsaturated fat (oleic acid))
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High-Oleic Canola/Flaxseed Oil Blend: Experimental |
Dietary Supplement: High-Oleic Canola/Flaxseed Oil Blend
Diets contained 35% energy as fat; of which 70% was provided by a 1:1 blend of high-oleic canola oil and flaxseed oil (high in monounsaturated fat (oleic acid) and omega-3 polyunsaturated fat (alpha-linolenic acid))
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Western Diet: Active Comparator |
Dietary Supplement: Western Dietary Control
Diets contained 35% energy as fat; of which 70% was provided by a blend of oils typical to the Western diet (high in saturated fat and omega-6 polyunsaturated fat (linoleic acid))
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Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Canada, Manitoba | |
Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba | |
Winnipeg, Manitoba, Canada, R3T 6C5 |
Principal Investigator: | Peter JH Jones, PhD | University of Manitoba - Richardson Centre for Functional Foods and Nutraceuticals |
Responsible Party: | Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba ( Peter J.H. Jones, PhD; Principal Investigator ) |
Study ID Numbers: | B2007:071 |
Study First Received: | June 17, 2009 |
Last Updated: | June 23, 2009 |
ClinicalTrials.gov Identifier: | NCT00927199 History of Changes |
Health Authority: | Canada: Ethics Review Committee |
High-Oleic Canola Oil Flaxseed Oil Monounsaturated Fatty Acids Polyunsaturated Fatty Acids Alpha Linolenic Acid |
Cardiovascular Hypercholesterolemia Lipids Inflammation Metabolism |
Flax Metabolic Diseases Hyperlipidemias Omega 3 Fatty Acid Metabolic Disorder |
Hypercholesterolemia Linoleate Dyslipidemias Lipid Metabolism Disorders Inflammation |
Metabolic Diseases Hyperlipidemias Cardiovascular Diseases |
Hypercholesterolemia Dyslipidemias Lipid Metabolism Disorders |