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Sponsors and Collaborators: |
University of Pennsylvania Robert Wood Johnson Foundation |
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Information provided by: | University of Pennsylvania |
ClinicalTrials.gov Identifier: | NCT00118989 |
Specific Aims:
Hypothesis: Curcuminoids decrease cellular proliferation in the colorectal mucosa of subjects with previously resected sporadic adenomatous colonic polyps.
Hypothesis: Curcuminoids increase apoptosis in colorectal mucosa of subjects with previously resected sporadic adenomatous colonic polyps.
Hypothesis: Curcuminoids decrease colorectal mucosa COX-2 expression in subjects with previously resected sporadic adenomatous colonic polyps.
Hypothesis: Curcuminoids decrease concentrations of urinary eicosanoids.
Condition | Intervention | Phase |
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Adenomatous Polyps |
Drug: Curcuminoids |
Phase II |
Study Type: | Interventional |
Study Design: | Prevention, Randomized, Double Blind (Subject, Investigator), Placebo Control, Parallel Assignment, Safety/Efficacy Study |
Official Title: | Phase II Double Blind Placebo-Controlled Trial of Curcuminoids' Effect on Cellular Proliferation, Apoptosis and COX-2 Expression in the Colorectal Mucosa of Subjects With Recently Resected Sporadic Adenomatous Polyps |
Estimated Enrollment: | 68 |
Study Start Date: | July 2005 |
Estimated Study Completion Date: | June 2009 |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Lisa Bowerman | (215) 573-4739 | lisa.bowerman@uphs.upenn.edu |
United States, Pennsylvania | |
University of Pennsylvania | Recruiting |
Philadelphia, Pennsylvania, United States, 19104 | |
Contact: Lisa Bowerman 215-573-4739 lisa.bowerman@uphs.upenn.edu | |
Principal Investigator: Carmen E Guerra, M.D. |
Principal Investigator: | Carmen E Guerra, M.D. | University of Pennsylvania |
Responsible Party: | University of Pennsylvania ( Carmen Guerra ) |
Study ID Numbers: | 802193 |
Study First Received: | July 2, 2005 |
Last Updated: | July 26, 2008 |
ClinicalTrials.gov Identifier: | NCT00118989 History of Changes |
Health Authority: | United States: Institutional Review Board |
Curcumin chemoprevention adenomatous polyps colorectal cancer |
Pathological Conditions, Anatomical Curcumin Digestive System Neoplasms Gastrointestinal Diseases Colonic Diseases Polyps Intestinal Diseases Rectal Diseases |
Intestinal Neoplasms Hyperplasia Digestive System Diseases Gastrointestinal Neoplasms Adenoma Colorectal Neoplasms Adenomatous Polyps Neoplasms, Glandular and Epithelial |
Pathological Conditions, Anatomical Neoplasms by Histologic Type Digestive System Neoplasms Gastrointestinal Diseases Colonic Diseases Polyps Intestinal Diseases Rectal Diseases Intestinal Neoplasms |
Neoplasms Neoplasms by Site Digestive System Diseases Gastrointestinal Neoplasms Adenoma Colorectal Neoplasms Adenomatous Polyps Neoplasms, Glandular and Epithelial |