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Sponsored by: |
Walter Reed Army Medical Center |
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Information provided by: | Walter Reed Army Medical Center |
ClinicalTrials.gov Identifier: | NCT00868712 |
The purpose of the study is to assess whether the use of warfarin, a commonly used anticoagulation drug, is associated with increased amounts of coronary artery calcification. Studies in animals and preliminary but small retrospective studies in humans have suggested a possible link to increased tissue calcification with use of this drug. The researchers will investigate this by assessing the amount of calcification seen in the coronary arteries using a specialized CT scan (electron-beam CT) and assessing to see if the amount is influenced by the amount of time a patient has been taking coumadin (warfarin). The researchers will exclude patients with known coronary artery disease, chronic kidney disease or hyperparathyroidism.
Condition |
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Coronary Calcification |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | Warfarin and Coronary Calcification Project |
Estimated Enrollment: | 100 |
Study Start Date: | May 2004 |
Estimated Study Completion Date: | January 2010 |
Estimated Primary Completion Date: | January 2010 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
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1
Warfarin use < 6 months
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2
Warfarin use 6-24 months
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3
Warfarin use >24 months
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Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Patients without known coronary heart disease, disorders of calcium metabolism or chronic kidney disease aged > 18 years who are referred to take or currently taking warfarin and are followed in the Anticoagulation Management Clinic at Walter Reed Army Medical Center (WRAMC).
Inclusion Criteria:
Exclusion Criteria:
Responsible Party: | Cardiology Service, Walter Reed Army Medical Center ( Todd C. Villines, MD ) |
Study ID Numbers: | WU# 04-12020 |
Study First Received: | March 24, 2009 |
Last Updated: | May 5, 2009 |
ClinicalTrials.gov Identifier: | NCT00868712 History of Changes |
Health Authority: | United States: Federal Government |
coronary calcification vitamin K dependent proteins warfarin |
Calcinosis Anticoagulants Metabolic Diseases Naphthoquinone Vitamins Menadione |
Vitamin K Menaquinone Phylloquinone Warfarin Metabolic Disorder |
Calcium Metabolism Disorders Calcinosis Anticoagulants Metabolic Diseases |
Therapeutic Uses Hematologic Agents Warfarin Pharmacologic Actions |