Pulsatile and Steady State Hemodynamics in Diastolic Heart Failure

This study is currently recruiting participants.

Verified by Klinikum Wels-Grieskirchen, August 2009

First Received: July 18, 2008 Last Updated: August 3, 2009 History of Changes

Sponsored by:	Klinikum Wels-Grieskirchen
Information provided by:	Klinikum Wels-Grieskirchen
ClinicalTrials.gov Identifier:	NCT00720525

Purpose

Over the past few years, there has been a growing appreciation that a large number of patients with heart failure have a relatively normal (or preserved) ejection fraction (NFNEF). Epidemiologically, HFNEF is most prevalent among elderly women, most of whom have hypertension, diabetes, or both and often coronary artery disease (CAD).

Increased arterial stiffness and/or wave reflections have been described in the same patient groups. Therefore, we speculate that pulsatile hemodynamics, representing arterial stiffness and/or arterial wave reflections, 1) may be altered in HFNEF patients, 2) this may contribute to pathophysiology of HFNEF, and 3) this may be used for the diagnosis of the syndrome.

Condition
Diastolic Heart Failure

Study Type:	Observational
Study Design:	Case Control, Prospective
Official Title:	Diagnostic Value of Measures of Pulsatile Versus Steady State Hemodynamics in Diastolic Heart Failure

Resource links provided by NLM:

MedlinePlus related topics: Heart Failure

U.S. FDA Resources

Further study details as provided by Klinikum Wels-Grieskirchen:

Biospecimen Retention: None Retained

Biospecimen Description:

Estimated Enrollment:	100
Study Start Date:	April 2008
Estimated Study Completion Date:	December 2009

Groups/Cohorts
1 Patients with diastolic heart failure
2 Patients without diastolic heart failure

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Probability Sample

Study Population

Patients undergoing invasive assessment for exertional dyspnea

Criteria

Inclusion Criteria:

exertional dyspnea
undergoing heart catheterization for diagnosis or exclusion of coronary artery disease
normal EF (> 50%)

Exclusion Criteria:

atrial fibrillation
more than mild valvular heart disease
pericardial disease
no informed consent

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00720525

Contacts

Contact: Thomas Weber, MD

0043 7242 415 2215

thomas.weber3@liwest.at

Locations

Austria
Cardiology Department, Klinikum Wels-Grieskirchen	Recruiting
Wels, Austria, 4600
Contact: Weber 0043 7242 415 2215
Principal Investigator: Thomas Weber, MD

Sponsors and Collaborators

Klinikum Wels-Grieskirchen

Investigators

Principal Investigator:

Thomas Weber, MD

Cardiology Department, Klinikum Wels-Grieskirchen, Austria

More Information

No publications provided

Responsible Party:	Cardiology Department, Klinikum Wels-Grieskirchen, Austria ( Dr Thomas Weber )
Study ID Numbers:	EK 248
Study First Received:	July 18, 2008
Last Updated:	August 3, 2009
ClinicalTrials.gov Identifier:	NCT00720525 History of Changes
Health Authority:	Austria: Ethikkommission

Keywords provided by Klinikum Wels-Grieskirchen:

arterial stiffness
arterial wave reflections
diastolic heart failure

Study placed in the following topic categories:

Heart Failure, Diastolic
Heart Failure
Heart Diseases

Additional relevant MeSH terms:

Heart Failure, Diastolic
Heart Failure
Heart Diseases
Cardiovascular Diseases

ClinicalTrials.gov processed this record on September 09, 2009