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Effects of Exercise on Patients With Hemiparetic Stroke
This study has been completed.
First Received: July 3, 2001   Last Updated: January 20, 2009   History of Changes
Sponsored by: Department of Veterans Affairs
Information provided by: Department of Veterans Affairs
ClinicalTrials.gov Identifier: NCT00018421
  Purpose

This randomized trial investigates the hypothesis that regular aerobic exercise training using a task specific gait training modality will improve cardiovascular fitness, functional mobility, and reduce risk factors for recurrent cardiovascular events in chronic hemiparetic stroke patients, when compared to matched controls performing just stretching.


Condition Intervention
Stroke
Hemiplegia
Cardiovascular Disease
Procedure: Treadmill Exercise

Study Type: Interventional
Study Design: Treatment, Randomized, Active Control, Parallel Assignment, Efficacy Study
Official Title: Effects of Exercise on Patients With Hemiparetic Stroke

Resource links provided by NLM:


Further study details as provided by Department of Veterans Affairs:

Study Start Date: July 1997
Estimated Study Completion Date: June 2001
Detailed Description:

The aims are to determine whether 6 months progressive graded treadmill training: 1) improves cardiovascular fitness levels and reduces the excessive energy demands of hemiparetic gait, as defined by oxygen consumption levels based on open circuit spirometry during peak and submaximal exercise ambulation tasks; 2) increases free living physical activity measured by portable kinematic recording devices and quantitative in vivo determination of energy expenditure using stable isotopes; and, 3) improves the cardiovascular-metabolic risk factor profile including measures of key endogenous fibrinolysis regulatory enzymes [plasma tissue plasminogen activator (t-PA) and its main circulating inhibitor (PAI-1)], fasting lipoprotein lipid profiles, blood pressure, and oral glucose tolerance and insulin responses. Measurements of body composition at baseline and after training will further determine the effects of aerobic exercise training on muscle mass and central obesity.

  Eligibility

Ages Eligible for Study:   40 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Males or Females Ages 40 yrs to 80 yrs who are chronic hemiparetic stroke patients.

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00018421

Locations
United States, Maryland
VA Maryland Health Care System
Baltimore, Maryland, United States, 21201
Sponsors and Collaborators
  More Information

No publications provided

Study ID Numbers: CADE-RA
Study First Received: July 3, 2001
Last Updated: January 20, 2009
ClinicalTrials.gov Identifier: NCT00018421     History of Changes
Health Authority: United States: Federal Government

Keywords provided by Department of Veterans Affairs:
Cerebrovascular Disorders
Exercise
Rehabilitation

Study placed in the following topic categories:
Hemiplegia
Cerebral Infarction
Stroke
Vascular Diseases
Central Nervous System Diseases
Ischemia
Brain Diseases
Cerebrovascular Disorders
Paralysis
Signs and Symptoms
Neurologic Manifestations
Brain Ischemia
Brain Infarction
Infarction

Additional relevant MeSH terms:
Hemiplegia
Cerebral Infarction
Stroke
Nervous System Diseases
Vascular Diseases
Central Nervous System Diseases
Brain Diseases
Cerebrovascular Disorders
Paralysis
Signs and Symptoms
Brain Ischemia
Neurologic Manifestations
Cardiovascular Diseases
Brain Infarction

ClinicalTrials.gov processed this record on September 04, 2009