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Sponsored by: |
University of Aarhus |
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Information provided by: | University of Aarhus |
ClinicalTrials.gov Identifier: | NCT00625001 |
Turner Syndrome (TS) is associated with osteopenia and osteoporosis. Reduced bone mineral density (BMD) and increased risk of fractures are present in many younger and middle-aged women with TS. The objective is therefore to describe longitudinal changes in BMD in TS. The study is an observational follow-up study. Examinations at baseline, after 5 and 10 years.
Bone mineral density is measured by dual energy x-ray absorptiometry (DEXA) and bone turnover by bone markers. Main Outcome Measures: Bone mineral density (BMD; grams/ square centimetre) were measured at lumbar spine, hip and the non-dominant forearm.
Condition |
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Turner Syndrome |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | Long Term Follow-up of Bone Mineral Density in Hormone Treated Turner Syndrome |
Blood samples
Enrollment: | 54 |
Study Start Date: | November 1994 |
Estimated Study Completion Date: | June 2010 |
Primary Completion Date: | October 1996 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
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1
Women with Turner syndrome
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2
Healthy control women
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Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Women with Turner syndrome
Inclusion Criteria:
Exclusion Criteria:
Responsible Party: | University of Aarhus ( MD, Dr. Med. Sci Claus Gravholt ) |
Study ID Numbers: | 1994/2424 |
Study First Received: | February 19, 2008 |
Last Updated: | February 19, 2008 |
ClinicalTrials.gov Identifier: | NCT00625001 History of Changes |
Health Authority: | Denmark: The Regional Committee on Biomedical Research Ethics |
Turner Syndrome bone mineral density estrogen replacement therapy dual energy x-ray absorptiometry |
Estrogens Gonadal Disorders Genital Dwarfism Chromosome Disorders Endocrine System Diseases Ovarian Dwarfism Hormones Sex Differentiation Disorders |
Monosomy X Turner Syndrome Urogenital Abnormalities Genetic Diseases, Inborn Endocrinopathy Congenital Abnormalities Gonadal Dysgenesis |
Disease Gonadal Disorders Chromosome Disorders Endocrine System Diseases Sex Differentiation Disorders Turner Syndrome Pathologic Processes |
Urogenital Abnormalities Genetic Diseases, Inborn Syndrome Sex Chromosome Disorders Congenital Abnormalities Gonadal Dysgenesis |