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Sponsored by: |
Tehran University of Medical Sciences |
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Information provided by: | Tehran University of Medical Sciences |
ClinicalTrials.gov Identifier: | NCT00461916 |
The purpose of this study is to determine whether half-dose depot triptorelin are as effective as reduced-dose daily buserelin in the controlled ovarian stimulation for intracytoplasmic sperm injection and embryo transfer
Condition | Intervention | Phase |
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Infertility |
Drug: Half-Dose Depot Triptorelin Drug: Reduced-Dose Daily Buserelin |
Phase IV |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Active Control, Parallel Assignment, Efficacy Study |
Official Title: | Half-Dose Depot Triptorelin Versus Reduced-Dose Daily Buserelin in a Long Protocol of Controlled Ovarian Stimulation for ICSI/ET |
Estimated Enrollment: | 182 |
Study Start Date: | May 2005 |
Study Completion Date: | December 2006 |
Significant doubts remain about which type of GnRH agonists [GnRHa] administration to be used in controlled ovarian stimulation [COS] cycles. The use of a single-dose depot long-acting GnRHa instead of a daily low dose preparation would be more comfortable for patients, however, inducing a profound pituitary desensitization, it increases the number of gonadotropin ampoules and the duration of the COS cycle without improving pregnancy rates or other clinical outcomes. Thus, some authors recommend a reduction of both dose and/or duration of GnRHa administration. Halving the dose of depot triptorelin, for instance, has been studied against its full dose administration since 1992 with rather similar clinical outcomes. Half-dose depot leuprolide acetate has also resulted in comparable clinical outcomes with standard daily injections in long GnRHa protocol. Reducing the daily doses of short acting GnRHa has been advocated to demonstrate equivalent results to standard doses. To our knowledge, however, the reduced daily doses have not been evaluated against half dose depot forms in long GnRHa protocols. Thus, we originally compared a half-dose depot triptorelin with reduced daily doses of short-acting buserelin in a long protocol for intracytoplasmic sperm injection and embryo transfer [ICSI/ET] cycles.
Ages Eligible for Study: | up to 35 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Iran, Islamic Republic of | |
Dr. Shariati Hospital | |
Tehran, Iran, Islamic Republic of, 14114 |
Principal Investigator: | Leili Safdarian, MD | Tehran University of Medical Sciences |
Study ID Numbers: | 5152 |
Study First Received: | April 17, 2007 |
Last Updated: | April 17, 2007 |
ClinicalTrials.gov Identifier: | NCT00461916 History of Changes |
Health Authority: | Iran: Ministry of Health |
half-dose depot triptorelin reduced-dose daily buserelin controlled ovarian stimulation long protocol ICSI |
Genital Diseases, Female Buserelin Infertility Antineoplastic Agents, Hormonal |
Contraceptive Agents Triptorelin Contraceptive Agents, Female Genital Diseases, Male |
Infertility Buserelin Antineoplastic Agents, Hormonal Antineoplastic Agents Contraceptive Agents Physiological Effects of Drugs Contraceptive Agents, Female Reproductive Control Agents |
Genital Diseases, Male Luteolytic Agents Pharmacologic Actions Genital Diseases, Female Triptorelin Fertility Agents, Female Therapeutic Uses Fertility Agents |