The study will compare markers of HIV disease progression among ART naive individuals receiving LLIN and a simple microbiological water purification system to historical comparison group from the same clinic settings.

We are enrolling 850 HIV infected ART naïve individuals into a randomized controlled trial comparing HIV disease progression in those receiving standard of care versus empiric deworming. Subjects are followed for 24 months and have serial measurements of HIV disease progression, and are evaluated serially for evidence of malaria, diarrhea and other co-morbidities. Participants in this study will have been consented for the collection of data on the frequency of malaria and diarrheal disease, their use of LLIN and water filtration and their compliance with TMP/SMX.

Inclusion Criteria:

• Participants must be at least 18 years of age.

• Participants must not be or have ever been on highly active antiretroviral therapy CD4 count at enrollment of

  • 350 cells/mm3
• WHO Stage I or II or Stage III based on pulmonary TB only and have completed 2 months of first-line therapy.
• Participants must be able and willing to participate and give written informed consent
• Participants must be able and willing to return for the scheduled follow-up visits

Exclusion Criteria:

• Age less than 18 years
• CD4 count <350 cells/mm3
• WHO Stage III or IV HIV Disease study (unless stage III for TB and have completed 2 months of first-line therapy)
• Participants must not be pregnant at the time of enrollment (by urine HCG testing)
• Patients with active tuberculosis who are on second or third line therapy or have not completed at least 2 months of first line TB therapy (Participants who have completed two months of first line TB therapy will be eligible for enrolment)