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Sponsors and Collaborators: |
National Institute of Neurological Disorders and Stroke (NINDS) Massachusetts General Hospital |
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Information provided by: | Office of Rare Diseases (ORD) |
ClinicalTrials.gov Identifier: | NCT00004457 |
OBJECTIVES:
I. Determine specific clinical features, molecular abnormalities, and laboratory-based biological markers of free radical stress that are associated with amyotrophic lateral sclerosis and influence disease severity.
Condition |
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Amyotrophic Lateral Sclerosis |
Study Type: | Observational |
Study Design: | Screening, Defined Population, Prospective Study |
Estimated Enrollment: | 75 |
Study Start Date: | March 1998 |
PROTOCOL OUTLINE: This is a screening and diagnostic study. Blood and urine samples are collected from patients every 2 months for 1 year. All samples are evaluated for measures of free radical damage and levels of the body's own antioxidant activity.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
PROTOCOL ENTRY CRITERIA:
--Disease Characteristics-- Clinically diagnosed probable or definite, sporadic or familial amyotrophic lateral sclerosis
--Patient Characteristics-- Pulmonary: No artificial ventilation required Other: No other neurodegenerative diseases No concurrent or history of unstable medical illness
Study ID Numbers: | 199/13650, MGH-97-7231, MGH-1K08NS01896 |
Study First Received: | October 18, 1999 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00004457 History of Changes |
Health Authority: | United States: Federal Government |
amyotrophic lateral sclerosis motor neuron disease neurologic and psychiatric disorders rare disease |
Lou Gehrig's Disease Neuromuscular Diseases Spinal Cord Diseases Mental Disorders Amyotrophic Lateral Sclerosis Rare Diseases |
Central Nervous System Diseases Sclerosis Neurodegenerative Diseases Degenerative Motor System Disease Motor Neuron Disease |
Pathologic Processes Neuromuscular Diseases Spinal Cord Diseases Amyotrophic Lateral Sclerosis Nervous System Diseases |
Central Nervous System Diseases Sclerosis Neurodegenerative Diseases Motor Neuron Disease |