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Sponsors and Collaborators: |
National Center for Research Resources (NCRR) Northwestern University |
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Information provided by: | Office of Rare Diseases (ORD) |
ClinicalTrials.gov Identifier: | NCT00004359 |
OBJECTIVES: I. Evaluate immunomodulation with extracorporeal photochemotherapy (ECP) in patients with epidermolysis bullosa acquisita. II. Investigate the effect of ECP on lymphocyte activity.
Condition | Intervention | Phase |
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Epidermolysis Bullosa Acquisita |
Drug: methoxsalen |
Phase II |
Study Type: | Interventional |
Study Design: | Treatment |
Estimated Enrollment: | 10 |
Study Start Date: | February 1996 |
PROTOCOL OUTLINE: Oral methoxsalen (8-MOP) is administered 90 minutes prior to leukapheresis. Blood mononuclear cells are exposed to ultraviolet A light for 3 hours, then returned to the patient. The process is repeated on 2 successive days. Patients are re-treated every 3 to 4 weeks for a total of 6 treatments or until the skin has cleared.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
- Active epidermolysis bullosa acquisita
Study ID Numbers: | 199/11928, NU-511 |
Study First Received: | October 18, 1999 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00004359 History of Changes |
Health Authority: | United States: Federal Government |
dermatologic disorders epidermolysis bullosa genetic diseases and dysmorphic syndromes rare disease |
Photosensitizing Agents Radiation-Sensitizing Agents Skin Diseases, Vesiculobullous Genetic Diseases, Inborn Skin Diseases Methoxsalen |
Skin Abnormalities Rare Diseases Epidermolysis Bullosa Congenital Abnormalities Skin Diseases, Genetic Epidermolysis Bullosa Acquisita |
Skin Diseases Skin Diseases, Vesiculobullous Physiological Effects of Drugs Skin Abnormalities Epidermolysis Bullosa Pharmacologic Actions Epidermolysis Bullosa Acquisita Photosensitizing Agents |
Genetic Diseases, Inborn Radiation-Sensitizing Agents Methoxsalen Therapeutic Uses Congenital Abnormalities Dermatologic Agents Skin Diseases, Genetic |