NIMH Pages about Clinical Research and Trials
Learn more about Clinical Research and Trials…
Publications
- A Participant's Guide to Mental Health Clinical Research
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This brochure, prepared by the National Institute of Mental Health (NIMH), provides answers to common questions about volunteering for mental health clinical research. NIMH is part of the National Institutes of Health (NIH), the primary Federal agency for conducting and supporting medical research.
Date: 2008
Science News
- Combination Treatment for Psychotic Depression Holds Promise
- August 07, 2009 • Science Update
A combination of an atypical antipsychotic medication and an antidepressant known as a selective serotonin reuptake inhibitor (SSRI) may be more effective in treating psychotic depression than an atypical antipsychotic alone, according to results from an NIMH-funded clinical study. - Searching for Risk Factors of Suicidal Events During Antidepressant Treatment
- May 29, 2009 • Science Update
A new set of analyses of the NIMH-funded Treatment for Adolescents with Depression Study (TADS) were conducted to better understand what may predict the development of suicidal events during treatment. The analyses, which were published in the May 2009 issue of the Journal of Clinical Psychiatry, showed that youths with suicidal thoughts and more severe depression prior to treatment were at higher risk for suicidal events while undergoing treatment. - HIV Prevention Program Gets a Boost From NIMH Recovery Act Funds
- May 26, 2009 • Press Release
Developing interventions to reduce the spread of HIV and other sexually transmitted infections among heterosexual men, couples and ethnically diverse populations continues to be complex and challenging. To help address this issue, NIMH awarded a two-year grant to David Pérez-Jiménez, Ph.D., at the University of Puerto Rico, to support the adaptation and assessment of an HIV and other sexually transmitted infection intervention designed for young, heterosexual Latino couples. This grant will use funds allocated to NIMH through the American Recovery and Reinvestment Act to promote economic recovery and spur advances in science and health. - Short-term Intensive Treatment Not Likely to Improve Long-term Outcomes for Children with ADHD
- March 26, 2009 • Science Update
Short-term Intensive Treatment Not Likely to Improve Long-term Outcomes for Children with ADHD - Brain Awareness Week Teaches Kids How Their Brains Work
- March 17, 2009 • Press Release
The 10th annual Brain Awareness Week (BAW), a science and health education fair held in various locations across the United States, teaches fifth through eighth grade students about the brain. In Washington, D.C., it will take place March 16-20, 2009, at the National Museum of Health and Medicine at Walter Reed Army Medical Center. Several institutes from the National Institutes of Health will provide interactive exhibits and lectures focusing on brain health and neuroscience on March 18th and 19th.
Meeting Summaries
- Child and Adolescent Effectiveness Research in Clinical Practice and Community Settings: Needs, Challenges, and Opportunities
- January 24, 2008 – January 25, 2008
Washington, D.C.
This workshop provided a forum for reviewing accomplishments and challenges in conducting effectiveness research in practice and other community settings and served as an opportunity for informally discussing promising approaches to further research. The focus of the meeting was on testing the effectiveness of treatment interventions for children and adolescents when delivered in clinical practice and other community settings, such as schools. - Strategies for Developing Novel Interventions for Neurodevelopmental Disorders
- October 11, 2007
Bethesda, Maryland
The goal of this workshop was to explore novel treatment approaches to neurodevelopmental disorders and strategies for promoting the development of innovative therapeutic approaches. - NCDEU Meeting
- June 01, 2006
Boca Raton, Florida
Named after the original NIMH New Clinical Drug Evaluation Unit clinical trials program, the NCDEU meeting has grown and evolved over the years to include a broad range of academic and industry investigators, practitioners, and NIMH and FDA staff.
Director’s Updates
- NIMH Perspective on Diagnosing and Treating Bipolar Disorder in Children
- September 03, 2007
A recently published research paper (September 2007, Archives of General Psychiatry) reported a 40-fold increase in the rate of diagnosing bipolar disorder in youth over the past decade. - NIMH Perspective on Antipsychotic Reimbursement: Using Results from the CATIE Cost Effectiveness Study
- December 01, 2006
The recent publication (December 1, 2006, American Journal of Psychiatry) of the cost-effectiveness results from the National Institute of Mental Health (NIMH)-funded Clinical Antipsychotic Trials in Intervention Effectiveness (CATIE) has raised questions among advocates, families, and clinicians about reimbursement policies for antipsychotic medications. - NIMH Perspective on Treating Alzheimer’s Patients with Antipsychotic Medications
- October 12, 2006
The recent publication of phase 1 results from the NIMH-funded Clinical Antipsychotic Trials in Intervention Effectiveness for Alzheimer's disease (CATIE-AD) in the New England Journal of Medicine provides new information about the use of several "atypical" antipsychotic medications for the treatment of psychotic symptoms in patients with Alzheimer's disease.
