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Sponsors and Collaborators: |
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Heart, Lung, and Blood Institute (NHLBI) |
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Information provided by: | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) |
ClinicalTrials.gov Identifier: | NCT00071175 |
The Lupus Genetics Studies and Lupus Family Registry & Repository are working to find the genes that reveal the causes of systemic lupus erythematosus (SLE, or lupus). The study is enrolling families of all ethnic backgrounds from the United States, Canada, Puerto Rico, and the Virgin Islands that have one or more living members diagnosed with SLE.
Condition |
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Systemic Lupus Erythematosus |
Study Type: | Observational |
Study Design: | Family-Based, Retrospective |
Official Title: | Lupus Genetic Studies; Lupus Family Registry & Repository |
DNA, sera, plasma, cell lines
Estimated Enrollment: | 18000 |
Study Start Date: | October 1995 |
Estimated Study Completion Date: | September 2012 |
Estimated Primary Completion Date: | September 2012 (Final data collection date for primary outcome measure) |
SLE is an often crippling and potentially fatal autoimmune disease that is nine times more prevalent in women than in men, and four times more likely to affect African American females than Caucasian females. It is suspected that a genetic predisposition along with environmental factors contribute to the clinical manifestation of SLE. The Lupus Genetics Studies consist of several familial SLE studies, including the Lupus Family Registry
Additionally, the Lupus Family Registry & Repository is the largest repository of its kind in North America.
In addition to the research done on site, the Repository serves as a national resource for scientists interested in conducting research on SLE and families either simplex or multiplex for lupus. Data, serum samples, and DNA samples are available to researchers. By collecting families in which two or more living individuals have been diagnosed with SLE, the study is utilizing the genetic link between the affected family members to discover disease-associated genes.
Records will be requested from the patients' treating physicians to document various lupus symptoms and related problems. One-time blood samples will be collected from the patients as well as from certain family members and an unrelated volunteer. There is no cost to participate and the study pays for sample draws and shipping.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Patients diagnosed with SLE Families with living members diagnosed with SLE
Inclusion Criteria:
Contact: Recruiters | 1-888-655-8787 | lupus-recruiters@lupus.omrf.org |
United States, Oklahoma | |
Oklahoma Medical Research Foundation | Recruiting |
Oklahoma City, Oklahoma, United States, 73104 | |
Contact: Recruiters 888-655-8787 lupus-recruiters@lupus.omrf.org |
Principal Investigator: | John B. Harley, MD, PhD | Member & Program Head, Arthritis and Immunology Research Program; Oklahoma Medical Research Foundation |
Responsible Party: | Oklahoma Medical Research Foundation ( John B. Harley, MD, PhD; Principal Investigator ) |
Study ID Numbers: | NIAMS-103, AI24717, AR42460, AR049084, AR52253, AR62277 |
Study First Received: | October 14, 2003 |
Last Updated: | November 14, 2008 |
ClinicalTrials.gov Identifier: | NCT00071175 History of Changes |
Health Authority: | United States: Federal Government |
Lupus Genetics |
Autoimmune Diseases Lupus Erythematosus, Systemic Lupus Connective Tissue Diseases |
Autoimmune Diseases Immune System Diseases Lupus Erythematosus, Systemic Connective Tissue Diseases |