Home
Search
Study Topics
Glossary
|
|
|
|
|
Sponsored by: |
Hadassah Medical Organization |
---|---|
Information provided by: | Hadassah Medical Organization |
ClinicalTrials.gov Identifier: | NCT00197327 |
This study studies labor epidural analgesia and compares dilute (0.0625%) with concentrated (0.25%) bupivacaine.
We hypothesize that patients randomize to receive the concentrated drug will require more drug, will have a more profound motor block, will be more likely to require instrumental delivery and will be less satisfied than those receiving dilute epidural drugs.
Condition | Intervention | Phase |
---|---|---|
Pain Labor Complications |
Drug: Epidural bupivacaine (0.25% versus 0.0625%) |
Phase III |
Study Type: | Interventional |
Study Design: | Randomized, Double-Blind, Dose Comparison, Parallel Assignment, Pharmacodynamics Study |
Official Title: | Analgesia Requirement and Maternal Satisfaction Following Epidural PCA in Nulliparous Labor: the Effect of a Four-Fold Change in Local Anesthetic Concentration. |
Estimated Enrollment: | 60 |
Study Start Date: | February 1998 |
Estimated Study Completion Date: | March 2000 |
This study examines the effect of two different local anesthetic concentrations used for epidural analgesia in labor. Patients are randomized to receive epidural bupivacaine, either as a concentrated (0.25%), or a dilute (0.0625%) solution, both administered by patient-controlled epidural analgesia (PCEA).
Ages Eligible for Study: | 18 Years to 40 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Israel | |
Hadassah Hebrew University Medical Center | |
Jerusalem, Israel, 91120 |
Principal Investigator: | Yehuda Ginosar, BSc MBBS | Hadassah-Hebrew University Medical Center |
Study ID Numbers: | Primip-ginosar-HMO-CTIL |
Study First Received: | September 13, 2005 |
Last Updated: | March 2, 2006 |
ClinicalTrials.gov Identifier: | NCT00197327 History of Changes |
Health Authority: | Israel: Ministry of Health |
Labor Pain Analgesia, Obstetrical Pharmacology Treatment Outcome |
Pregnancy Complications Labor Pain Obstetric Labor Complications Central Nervous System Depressants Anesthetics |
Bupivacaine Pain Peripheral Nervous System Agents Anesthetics, Local |
Pregnancy Complications Sensory System Agents Therapeutic Uses Physiological Effects of Drugs Obstetric Labor Complications Central Nervous System Depressants |
Anesthetics Bupivacaine Peripheral Nervous System Agents Central Nervous System Agents Pharmacologic Actions Anesthetics, Local |