Comparison of Cardiac Computed Tomography for the Detection of Coronary Artery Disease With Nuclear Stress Test

This study is currently recruiting participants.

Verified by Providence VA Medical Center, January 2009

First Received: July 14, 2006 Last Updated: January 14, 2009 History of Changes

Sponsored by:	Providence VA Medical Center
Information provided by:	Providence VA Medical Center
ClinicalTrials.gov Identifier:	NCT00352937

Purpose

To compare the efficacy of 16-row multi-detector CT (MDCT) with standard myocardial perfusion imaging in detecting coronary artery disease (CAD) in patients without a previously established diagnosis of CAD.

Condition	Phase
Coronary Arteriosclerosis	Phase III

Study Type:	Observational
Study Design:	Cohort, Prospective
Official Title:	Comparison of Cardiac Computed Tomography for the Detection of Coronary Artery Disease With Nuclear Stress Test

Resource links provided by NLM:

MedlinePlus related topics: CT Scans Coronary Artery Disease

U.S. FDA Resources

Further study details as provided by Providence VA Medical Center:

Biospecimen Retention: None Retained

Biospecimen Description:

Estimated Enrollment:	100
Study Start Date:	March 2006
Estimated Study Completion Date:	December 2009

Detailed Description:

Nuclear stress testing is currently the established non-invasive modality in detecting flow-obstructing coronary artery disease (CAD).

Recently, multi-detector CT (MDCT) has emerged as a new modality that offers a non-invasive means to directly visualize coronary anatomy and any CAD. Studies have shown that MDCT has excellent sensitivity and a high negative predictive value in detecting significant CAD.

The purpose of this study is to compare MDCT with nuclear stress testing for detecting CAD in previously undiagnosed patients.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

All patients without prior CAD referred for nuclear stress testing

Criteria

Inclusion Criteria:

Referred for a clinical indicated stress SPECT MPI
Adequate IV access in both arms

Exclusion Criteria:

History of coronary angioplasty or stent placement
History of coronary bypass surgery
Angiographic history of flow-limiting CAD
Documented history of elevated cardiac markers
Documented history of injury or infarct on ECG
Absence of sinus rhythm
Current history of renal insufficiency
Known allergy to contrast dye
Pregnant

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00352937

Contacts

Contact: Victor H Shin, MD

917-572-7939

vshinmd@gmail.com

Locations

United States, Rhode Island
Providence Veterans Affairs Medical Center	Recruiting
Providence, Rhode Island, United States, 02908
Contact: Victor H Shin, MD 917-572-7939 vshinmd@gmail.com
Contact: Wen-Chih Wu, MD 401-273-7100 ext 2688 Wen-Chih.Wu@va.gov

Sponsors and Collaborators

Providence VA Medical Center

Investigators

Principal Investigator:	Wen-Chih Wu, MD	Providence VAMC
Principal Investigator:	Victor H Shin, MD	Providence VAMC

More Information

No publications provided

Responsible Party:	Providence VA Medical Center ( Wen-Chih Wu, MD )
Study ID Numbers:	1124528
Study First Received:	July 14, 2006
Last Updated:	January 14, 2009
ClinicalTrials.gov Identifier:	NCT00352937 History of Changes
Health Authority:	United States: Federal Government

Keywords provided by Providence VA Medical Center:

Coronary Arteriosclerosis
Tomography, X-Ray Computed
Tomography, Emission-Computed, Single-Photon

Study placed in the following topic categories:

Arterial Occlusive Diseases
Coronary Disease
Heart Diseases
Myocardial Ischemia
Vascular Diseases

Stress
Ischemia
Arteriosclerosis
Coronary Artery Disease

Additional relevant MeSH terms:

Arterial Occlusive Diseases
Coronary Disease
Heart Diseases
Myocardial Ischemia

Vascular Diseases
Cardiovascular Diseases
Arteriosclerosis
Coronary Artery Disease

ClinicalTrials.gov processed this record on September 03, 2009