Inclusion Criteria:

• Histologically or cytologically documented NSCLC, including squamous cell carcinoma, adenocarcinoma (including bronchoalveolar cell), and large cell anaplastic carcinoma (including giant and clear cell carcinomas).
• Eligible Disease Stages: Inoperable IIIA and Selected IIIB
• Local radiation oncologist must approve patient eligibility prior to entry on study.
• Patients must have measurable disease.

• Prior Therapy:

  • ≥ 2 weeks since formal exploratory thoracotomy.
  • No prior chemotherapy or radiation therapy for NSCLC.
• ECOG performance status 0-1

• Required Initial Laboratory Values (must be submitted within 16 days prior to registration):

  • Granulocytes ≥ 1,500/µl
  • Platelets ≥ 100,000/µl
  • Calculated Creatinine Clearance ≥ 20 cc/min
  • Bilirubin < 1.5 mg/dl
  • AST (SGOT) < 2 x ULN

  • INR > 0.8 < 1.2*

    • Values apply exclusively to patients not being treated with warfarin. Values for patients being treating with warfarin should fall within the following therapeutic range: > 2.0 < 3.0.

Exclusion Criteria:

• Currently active second malignancy other than non-melanoma skin cancers. Patients are not considered to have a "currently active" malignancy if they have completed therapy and are considered by their physician to be at less than 30% risk of relapse.
• Pregnant or nursing because of significant risk to the fetus/infant.
• Age <18 years.
• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
• No HIV-positive patients receiving combination anti-retroviral therapy. Because patients with immune deficiency are at increased risk of lethal infections when treated with marrow-suppressive therapy
• One-second forced expiratory volume (FEV1) <50% or hemoglobin-corrected carbon monoxide diffusion capacity (DLCO) <50% of predicted, as measured within 21 days of study entry
• Symptoms of esophageal dysfunction (dysphagia, odynophagia, or inability to swallow solid food) within 4 weeks prior to study randomization. Patients must not require prophylactic placement of percutaneous enterogastrostomy (PEG) tube or other non-oral nutritional supplement methods
• Weight loss of > 10% in the past 3 months.