Effects of Fasting and Exercise on Insulin and GH Signaltransduction in Muscle and Fat - Full Text View

Sponsored by:	University of Aarhus
Information provided by:	University of Aarhus
ClinicalTrials.gov Identifier:	NCT00817440

Purpose

Hypothesis: under fasting there will primarily be an activation of growth hormone(GH) signalpathways and a inhibition of insulin signalpathways, and the opposite will happen under physical activity.

Primarily we will investigate markers for GH and insulin signaltransduction in muscle- and fat-biopsies after fasting for 72 hours and after 1 hour of ergometer-cycling at 65% Vo2max. In addition to this we will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.

Condition	Intervention
Healthy	Other: Exercise Other: Fasting

Study Type:	Interventional
Study Design:	Basic Science, Randomized, Open Label, Uncontrolled, Crossover Assignment, Efficacy Study
Official Title:	Effects of Fasting and Exercise on Insulin and GH Signaltransduction in Muscle and Fat

Resource links provided by NLM:

MedlinePlus related topics: Exercise and Physical Fitness

Drug Information available for: Insulin

U.S. FDA Resources

Further study details as provided by University of Aarhus:

Primary Outcome Measures:

Growth hormone and insulin signal pathways [ Time Frame: 30 min ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

aminoacid and glucose turnover [ Time Frame: 4 hours ] [ Designated as safety issue: No ]

Estimated Enrollment:	8
Study Start Date:	December 2008
Primary Completion Date:	May 2009 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Control: No Intervention control: muscle and fat biopsies and basal aminoacid and glucose turnover
Exercise: Experimental 1 hour ergometer cycling on 65% of Vo2max, and then the same as arm 1.	Other: Exercise 1 hour ergometer cycling on 65% of Vo2max, and then the same as arm 1.
Fasting: Experimental 3 days of fasting and then the same as arm 1	Other: Fasting 3 days of fasting and then the same as arm 1

Eligibility

Ages Eligible for Study:	18 Years to 45 Years
Genders Eligible for Study:	Male
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

healthy men
Body mass index (BMI) 20-26
age 18-45 years

Exclusion Criteria:

any kind of disease
any use of medicine

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00817440

Locations

Denmark, Jylland
Aarhus sygehus
Aarhus, Jylland, Denmark, 8000

Sponsors and Collaborators

University of Aarhus

More Information

No publications provided

Responsible Party:	endokrinologiskforskningslaboratorium M, Aarhus sygehus ( Mikkel Vendelbo MD )
Study ID Numbers:	16.12.2008
Study First Received:	January 5, 2009
Last Updated:	July 7, 2009
ClinicalTrials.gov Identifier:	NCT00817440 History of Changes
Health Authority:	Denmark: Ethics Committee

Keywords provided by University of Aarhus:

growth hormone insulin signaltransduction signalpathways
growth hormone and insulin signalpathways

Study placed in the following topic categories:

Hypoglycemic Agents
Healthy
Hormones
Insulin

Additional relevant MeSH terms:

Hypoglycemic Agents
Physiological Effects of Drugs
Pharmacologic Actions
Insulin

ClinicalTrials.gov processed this record on September 02, 2009