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Sponsored by: |
National Taiwan University Hospital |
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Information provided by: | National Taiwan University Hospital |
ClinicalTrials.gov Identifier: | NCT00302588 |
Investigate the final diagnosis and treatment result of metastatic cervical carcinoma of unknown primary
Condition |
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Metastasis Cervical Lymph Nodes of Unknown Primary Carcinoma |
Study Type: | Observational |
Study Design: | Natural History, Longitudinal, Random Sample, Retrospective Study |
Estimated Enrollment: | 100 |
Study Start Date: | January 2006 |
Estimated Study Completion Date: | February 2006 |
Carcinoma of unknown primary (CUP) is defined as biopsy-proven metastasis of an epithelial malignancy in the absence of an identifiable primary site after complete history and physical examination, basic laboratory studies, chest X-ray and additional directed studies indicated by positive findings during the initial work-up.
It is characterized by its slow local development and its high metastatic potential.1,2 Patients with CUP represent 4–10% of all new cancer patients.3,4 The presenting sites of metastasis identified pathologically, radiographically or by physical examination were found most frequently in the lymph nodes (37.1%), followed by the liver, bone, lung, pleura/pleural space, brain, peritoneum, adrenal and skin. Of the lymph nodes of metastasis, the supraclavicular cervical area is the leading site (31.3%), followed by the mediastinum, axilla, retroperitonium, and inguina.5 The incidence of metastatic cervical CUP (MCCUP) varies between 2% and 9% of all head and neck cancers.6-8 The level of cervical metastatic involvement may give some clue as to the likely primary site. A submandibular mass (level I) would most commonly be related to a primary in the oral cavity or skin. Level II nodes, including the jugulodigastric node, may point to a primary in the oral cavity, oropharynx, or supraglottic larynx. Tumours of the nasopharynx generally spread to level II or the posterior triangle, as well as retropharyngeal nodes. Middle and lower jugular nodes (levels III and IV) are more likely related to a laryngeal or hypopharyngeal cancer. Metastatic disease restricted to the supraclavicular region is often due to an infraclavicular primary site.9 The prognosis is different according to the involved lymph node level and possible primary site. Modern cancer management relies heavily on recognition of the primary tumor; thus the absence of a primary site poses major diagnostic and therapeutic problems. The patient benefits from identification of the initial tumor site because postoperative irradiation ports may be reduced and because surveillance for recurrence may be improved.10 In order to identify the likely primary site of MCCUP and compare the prognoses of known and unknown primary groups, we report the results according to the different levels of metastatic cervical lymph nodes.
Ages Eligible for Study: | 20 Years to 75 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
-
Contact: Ching-Ting Tan, MD, PhD | 886-2-23123456 ext 5222 | christin@ha.mc.ntu.edu.tw |
Taiwan | |
National Taiwan University Hospital | Recruiting |
Taipei, Taiwan | |
Contact: Ching-Ting Tan, MD, PhD 886-2-23123456 ext 5222 christin@ha.mc.ntu.edu.tw |
Principal Investigator: | Ching-Ting Tan, MD, PhD | National Taiwan University Hospital |
Study ID Numbers: | 9461701257 |
Study First Received: | March 12, 2006 |
Last Updated: | March 12, 2006 |
ClinicalTrials.gov Identifier: | NCT00302588 History of Changes |
Health Authority: | Taiwan: Department of Health |
metastatic carcinoma cervical lymph nodes unknown primary diagnosis result |
Neoplasms, Unknown Primary Neoplasm Metastasis Neoplasms, Glandular and Epithelial Carcinoma |
Neoplastic Processes Neoplasms Neoplasms, Unknown Primary Pathologic Processes |
Neoplasms by Histologic Type Neoplasm Metastasis Neoplasms, Glandular and Epithelial Carcinoma |