Functional Magnetic Resonance Imaging (fMRI) Studies in Pathological Gambling (PG) and Obsessive-Compulsive Disorder (OCD)

This study is currently recruiting participants.

Verified by Mount Sinai School of Medicine, May 2008

First Received: September 13, 2005 Last Updated: May 23, 2008 History of Changes

Sponsors and Collaborators:	Mount Sinai School of Medicine Abbott
Information provided by:	Mount Sinai School of Medicine
ClinicalTrials.gov Identifier:	NCT00211822

Purpose

This study will explore the brain processes associated with inhibition and rewards in pathological gamblers and people with obsessive compulsive disorder.

Condition	Intervention
Pathological Gambling Obsessive Compulsive Disorder	Procedure: fMRI

Study Type:	Interventional
Study Design:	Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Safety/Efficacy Study
Official Title:	fMRI Studies in Pathological Gambling and Obsessive-Compulsive Disorder

Resource links provided by NLM:

MedlinePlus related topics: Compulsive Gambling Obsessive-Compulsive Disorder

U.S. FDA Resources

Further study details as provided by Mount Sinai School of Medicine:

Primary Outcome Measures:

The primary objective of this study is to explore the brain processes associated with inhibition and rewards in individuals diagnosed with OCD and pathological gambling.

Secondary Outcome Measures:

A secondary objective is to explore the brain processes associated with inhibition and rewards in individuals diagnosed with OCD and pathological gambling after treatment with topiramate.

Estimated Enrollment:	48
Study Start Date:	November 2004
Estimated Study Completion Date:	November 2006

Detailed Description:

This study will explore the brain processes associated with inhibition and rewards in pathological gamblers and people with obsessive compulsive disorder. Participants who are diagnosed with PG or OCD will undergo one fMRI scan, and those entering treatment with topiramate will undergo two fMRI scans, one at the start of the study and one at termination (approximately 12-14 weeks later). The brain scan will last about one and a half hours and will involve performing tasks while in the scanner. Participants must be between the ages of 18-55 and in good medical condition.

Eligibility

Ages Eligible for Study:	18 Years to 55 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Male or female adults diagnosed with pathological gambling or obsessive compulsive disorder aged 18-55.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00211822

Contacts

Contact: Ashley Braun

(212) 369-5123

ashley.braun@mssm.edu

Locations

United States, New York
Mount Sinai School of Medicine	Recruiting
New York, New York, United States, 10029
Contact: Kim Suah 212-369-5123 suah.kim@mssm.edu
Principal Investigator: Eric Hollander, MD

Sponsors and Collaborators

Mount Sinai School of Medicine

Abbott

Investigators

Principal Investigator:

Eric Hollander, MD

Mount Sinai School of Medicine

More Information

Additional Information:

Mount Sinai School of Medicine Compulsive, Impulsive and Anxiety Disorders Program This link exits the ClinicalTrials.gov site

No publications provided

Study ID Numbers:	GCO#04-1034
Study First Received:	September 13, 2005
Last Updated:	May 23, 2008
ClinicalTrials.gov Identifier:	NCT00211822 History of Changes
Health Authority:	United States: Institutional Review Board

Keywords provided by Mount Sinai School of Medicine:

Pathological Gambling
Obsessive-Compulsive Disorder
PG
OCD
fMRI

Study placed in the following topic categories:

Impulse Control Disorders
Gambling
Anxiety Disorders
Mental Disorders
Obsessive-Compulsive Disorder

Additional relevant MeSH terms:

Impulse Control Disorders
Pathologic Processes
Gambling
Disease

Anxiety Disorders
Mental Disorders
Obsessive-Compulsive Disorder

ClinicalTrials.gov processed this record on September 02, 2009