|
|
Home
Search
Study Topics
Glossary
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
||||||||||||||||||||||||||||||||||||
| Sponsors and Collaborators: |
University of Copenhagen Danish Institute of Fisheries Research, Denmark |
|---|---|
| Information provided by: | University of Copenhagen |
| ClinicalTrials.gov Identifier: | NCT00432952 |
Purpose
The acute effects of farmed rainbow trout, fed by various feeds versus a control meal with poultry meat on cardiovascular risk markers and plasma protein expression are investigated.
The hypotheses of the study are that if the feed are changed from a marine origin to primarily a vegetable origin the content of long chain n-3 poly unsaturated fatty acids (n-3 PUFA) will decrease in the meat and thus possibly result in a decreased effect on health. Furthermore, the feed of the trouts are also expected to give rise to differences in the human plasma protein profile and fatty acid composition after consumption, which could be associated with physiological effects.
| Condition | Intervention |
|---|---|
|
Cardiovascular Diseases Metabolic Syndrome |
Behavioral: Intake of rainbow trout from different feeding conditions versus a control poultry meal |
| Study Type: | Interventional |
| Study Design: | Prevention, Randomized, Single Blind, Active Control, Crossover Assignment, Bio-availability Study |
| Estimated Enrollment: | 6 |
| Study Start Date: | January 2007 |
| Estimated Study Completion Date: | January 2009 |
| Primary Completion Date: | March 2007 (Final data collection date for primary outcome measure) |
In a controlled, single blinded human single meal study the acute effects of farmed rainbow trout, fed by various feeds versus a control meal with poultry meat on cardiovascular risk markers and plasma protein expression are investigated. 6 healthy men, age 40-70, will be randomized to trout fed on only vegetable, only marine and a mix of different compositions of vegetable and marine feeds. Outcome variables are blood pressure, pulse wave analyse, pulse wave velocity, plasma protein profile, and plasma triglycerides.
The hypotheses of the study are that if the feed are changed from a marine origin to primarily a vegetable origin the content of long chain n-3 poly unsaturated fatty acids (n-3 PUFA) will decrease in the meat and thus possibly result in a decreased effect on health. Furthermore, the feed of the trouts are also expected to give rise to differences in the human plasma protein profile and fatty acid composition after consumption, which could be associated with physiological effects.
Eligibility| Ages Eligible for Study: | 40 Years to 70 Years |
| Genders Eligible for Study: | Male |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Denmark | |
| Institute of Human Nutrition, University of Copenhagen | |
| Frederiksberg C, Denmark, 1958 | |
| Principal Investigator: | Lotte Lauritzen, Ph.D | University of Copenhagen |
More Information
| Responsible Party: | Dept. of Human Nutrtion ( Associate profesor Lotte lauritzen ) |
| Study ID Numbers: | M186 |
| Study First Received: | February 7, 2007 |
| Last Updated: | August 12, 2008 |
| ClinicalTrials.gov Identifier: | NCT00432952 History of Changes |
| Health Authority: | Denmark: The Danish National Committee on Biomedical Research Ethics |
|
Cardiovascular Heart Disease |
|
Heart Diseases |
|
Pathologic Processes Disease Syndrome Cardiovascular Diseases |
