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Sponsored by: |
Danish Headache Center |
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Information provided by: | Danish Headache Center |
ClinicalTrials.gov Identifier: | NCT00363571 |
After infusion / injection of Glyceryl trinitrate and Diamox it is wished to study the effect of drugs on the cerebral haemodynamics such as Cerebral blod flow and cerebral blod volume.
Condition | Intervention |
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Migraine |
Drug: GTN, Diamox |
Study Type: | Interventional |
Study Design: | Educational/Counseling/Training, Randomized, Double-Blind, Placebo Control, Crossover Assignment |
Official Title: | The Effect of Glyceryl Trinitrate (GTN) and Diamox on Cerebral Haemodynamics Judged With the Help of 3-Tesla MRI. |
Estimated Enrollment: | 12 |
Study Start Date: | August 2006 |
Estimated Study Completion Date: | May 2007 |
Experimental headache model open a unike opportunity to study the pathophysiological mechanisms behind headache in general and migrane in particular. Previous studies have used various techniques to study the cerebral haemodynamics as a basis for the headache pathophysiology. We wish to use a 3-Tesa MRI so study the cerebral haemodynamics after application of various pharmacological substances. The most used experimental headache model is the glyceryl trinitrate model (GTN). Where infusion of the NO donor GTN induces headache and changes in the cerebral arteries. On the other hand injection of Diamox (Acetazolamide) apparently causes increase of the cerebral blod flow with out dilation of the arteries. We wish to study the precise effect of GTN and diamox on the cerebral haemodynamics such as Cerebral blod flow (CBF) and Cerebral blod volume (CBV) via a 3-Tesla MRI.
Ages Eligible for Study: | 18 Years to 55 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Mohammad Sohail Asghar, MD | +4543232161 | asgsoh01@glostruphosp.kbhamt.dk |
Denmark | |
Danish Headache Center, Neurological Dep. Glostrup hospital | |
Glostrup, Denmark, 2770 |
Study Chair: | Messoud Ashina, MD,Ph.D | Danish Headache Center |
Study ID Numbers: | KA-20060084 |
Study First Received: | August 14, 2006 |
Last Updated: | August 14, 2006 |
ClinicalTrials.gov Identifier: | NCT00363571 History of Changes |
Health Authority: | Denmark: The Danish National Committee on Biomedical Research Ethics |
Nitroglycerin Carbonic Anhydrase Inhibitors Migraine Disorders Diuretics Headache Acetazolamide |
Central Nervous System Diseases Headache Disorders, Primary Cardiovascular Agents Brain Diseases Anticonvulsants Headache Disorders |
Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Diuretics Nervous System Diseases Acetazolamide Central Nervous System Diseases Headache Disorders, Primary Enzyme Inhibitors Cardiovascular Agents |
Brain Diseases Pharmacologic Actions Headache Disorders Carbonic Anhydrase Inhibitors Natriuretic Agents Migraine Disorders Therapeutic Uses Central Nervous System Agents Anticonvulsants |