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Sponsors and Collaborators: |
University of British Columbia Stanley Medical Research Institute |
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Information provided by: | University of British Columbia |
ClinicalTrials.gov Identifier: | NCT00175513 |
This is an 18 week (2 weeks run-in, 16 weeks double blind) trial, to determine if an antiviral drug, valacyclovir (Valtrex) is helpful in treating the symptoms of psychosis, a form of a mental disorder.
Condition | Intervention | Phase |
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Psychosis |
Drug: Valacyclovir (Valtrex) |
Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Uncontrolled, Single Group Assignment, Efficacy Study |
Official Title: | V3: Vancouver-Victoria Valacyclovir Trial for Early Psychosis |
Estimated Enrollment: | 100 |
Study Start Date: | September 2005 |
Estimated Study Completion Date: | December 2008 |
Estimated Primary Completion Date: | December 2008 (Final data collection date for primary outcome measure) |
There is evidence that some of the symptoms of psychosis may be related to past infection with common viruses.
Researchers are looking to recruit a total of 100 subjects with evidence in the past, of exposure to at least 1 of 3 viruses. The viruses include herpes type 1 (HSV-1, which causes cold sores of the lip and has affected about 6/10 people in Vancouver), herpes type 2 (HSV-2 which causes genital sores, and has affected less than 1/10 people in Vancouver) and cytomegalovirus (CMV, which causes few symptoms but has affected 8/10 people in Vancouver). People who have been infected with these viruses in the past develop antibodies in the blood. The antibodies can be measured in blood, and are a test of whether or not there was infection in the past, and possibly affecting the symptoms of psychosis.
Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Barbara Humphries | 604-524-7844 | barhumph@interchange.ubc.ca |
Canada, British Columbia | |
Peace Arch Hospital | Recruiting |
White Rock, British Columbia, Canada | |
Eric Martin Pavilion | Recruiting |
Victoria, British Columbia, Canada |
Principal Investigator: | William Honer, MD | University of British Columbia |
Responsible Party: | University of British Columbia ( Dr. William Honer ) |
Study ID Numbers: | C04-0503, FHA: 2005-07, TPD: 094295 |
Study First Received: | September 11, 2005 |
Last Updated: | September 2, 2008 |
ClinicalTrials.gov Identifier: | NCT00175513 History of Changes |
Health Authority: | Canada: Health Canada |
Psychosis early psychosis first episode psychosis schizophrenia schizoaffective |
schizophreniform bipolar disorder valtrex valacyclovir. |
Valacyclovir Schizophrenia Anti-Infective Agents Mental Disorders |
Bipolar Disorder Psychotic Disorders Antiviral Agents Schizophrenia and Disorders with Psychotic Features |
Valacyclovir Anti-Infective Agents Mental Disorders Therapeutic Uses |
Psychotic Disorders Antiviral Agents Pharmacologic Actions Schizophrenia and Disorders with Psychotic Features |