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Sponsors and Collaborators: |
University of California, San Francisco University of California, Berkeley |
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Information provided by: | University of California, San Francisco |
ClinicalTrials.gov Identifier: | NCT00254605 |
The purpose of this study is to determine whether the structure and function of the human retina can be studied with high resolution in patients with inherited retinal degenerations using the Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO).
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | High Resolution Retinal Imaging in Patients With Inherited Retinal Degenerations |
Estimated Enrollment: | 130 |
Study Start Date: | November 2005 |
Estimated Study Completion Date: | November 2011 |
Retinal degenerations are a group of inherited diseases that result in progressive death of the vision cells, or photoreceptors. Currently there is no treatment or cure for any of these diseases and they ultimately cause blindness in affected patients. We propose to investigate the structure and function of the human retina in patients with inherited retinal degenerations using the Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO).
We will correlate the images of retinal structure produced by the AOSLO with Optical Coherence Tomography (OCT) images of the retina. In addition, we will study the vision of individual photoreceptors using the AOSLO to perform a novel technique, microperimetry, in patients with retinal degenerations. We will compare the results of microperimetry with standard measures of vision used in Ophthalmology clinics, including visual acuity, automated perimetry, fundus photography and multifocal electroretinography (mfERG).
The results of this work will provide insight into the mechanism of vision loss among patients with diverse retinal disorders. Specifically, we will study cone structure and function in patients with retinal degenerations with different etiologies: retinitis pigmentosa, a disease usually caused by rod-specific mutations; cone-rod dystrophy, which primarily affects cones rather than rods; and Best's disease, a disease caused by a defect in the retinal pigment epithelium (RPE). In addition, we will study the effect that lipofuscin, a byproduct of photoreceptor metabolism that accumulates in the RPE in diseases such as Stargardt's disease, Best's disease and age-related macular degeneration (AMD), has on cone structure and function, with the goal of understanding how these diseases cause blindness. Better understanding of the mechanisms of vision loss in patients with retinal degeneration should ultimately lead to treatments for these blinding conditions.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Patients with inherited retinal degenerations, including retinitis pigmentosa, cone-rod dystrophy, Stargardt disease, choroideremia, x-linked retinoschisis and Best disease. We are also studying patients with age-related macular degeneration.
Inclusion Criteria:
Exclusion Criteria:
Contact: Jacque L. Duncan, M.D. | 415-514-4241 | duncanj@vision.ucsf.edu |
Contact: Monique Trinidad, B.S. | 415-476-0444 | monique.trinidad@ucsfmedctr.org |
United States, California | |
University of California Retinal Degenerations Clinic | Recruiting |
San Francisco, California, United States, 94143 | |
Contact: Jacque L. Duncan, M.D. 415-514-4241 duncanj@vision.ucsf.edu | |
Contact: Monique Trinidad, B.S. 415-476-0444 monique.trinidad@ucsfmedctr.org | |
Principal Investigator: Jacque L. Duncan, M.D. |
Principal Investigator: | Jacque L. Duncan, M.D. | University of California, San Francisco |
Responsible Party: | University of California, San Francisco ( Jacque Duncan, M.D./Associate Professor, Clinical Ophthalmology ) |
Study ID Numbers: | H12225-27221-0+1 |
Study First Received: | November 14, 2005 |
Last Updated: | February 12, 2009 |
ClinicalTrials.gov Identifier: | NCT00254605 History of Changes |
Health Authority: | United States: Institutional Review Board |
imaging adaptive optics scanning laser ophthalmoscope optical coherence tomography electroretinography |
Pigmentary Retinopathy Cone Rod Dystrophy Genetic Diseases, Inborn Eye Diseases Retinitis Pigmentosa |
Retinitis Eye Diseases, Hereditary Retinal Degeneration Macular Degeneration Retinal Diseases |
Genetic Diseases, Inborn Eye Diseases Retinitis Pigmentosa Retinitis |
Eye Diseases, Hereditary Retinal Degeneration Macular Degeneration Retinal Diseases |