Wellbutrin XL Effects on SSRIs Induced Changes - Full Text View

Sponsored by:	Indiana University School of Medicine
Information provided by:	Indiana University
ClinicalTrials.gov Identifier:	NCT00456820

Purpose

The purpose of this study is to find out differences in activation of mood regulating areas of the brain in response to negative and positive pictures, before and after 6 weeks of additional Wellbutrin XL treatment.

Participants should have been treated for depression with an SSRI medication (e.g., Prozac, Zoloft, Paxil, Celexa or Lexapro) and have decreased depression symptoms but also be experiencing side effects of medications such as sexual side effects and feelings of apathy (indifference, lack of interest) and lack of full emotional response.

We will first take a brain scan to measure activity in different parts of the brain, while subjects are seeing pictures, using Magnetic Resonance Imaging (MRI) scan. Then we will add Wellbutrin XL - another well-known antidepressant that acts by increasing the chemical dopamine in the brain, to subjects' treatment. Wellbutrin addition is useful in decreasing the sexual side effects of SSRIs. After treatment with Wellbutrin XL for 6 weeks subjects will have a second MRI scan with picture rating.

Condition	Intervention	Phase
Depression Side Effects Sexual Dysfunction Apathy	Drug: Wellbutrin XL	Phase IV

Study Type:	Interventional
Study Design:	Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Efficacy Study
Official Title:	Wellbutrin XL Effects on SSRIs Induced Changes in the Reactivity of the Frontal Cortex and Limbic System to Emotional Stimuli: An fMRI Study

Resource links provided by NLM:

MedlinePlus related topics: Depression MRI Scans Nuclear Scans

Drug Information available for: Bupropion hydrochloride Bupropion

U.S. FDA Resources

Further study details as provided by Indiana University:

Primary Outcome Measures:

Activation and connectivity of frontal cortex and limbic region as measured by MRI scan at baseline and six weeks from baseline
Improvement of scores on Apathy Evaluation Scale and Changes in Sexual Functioning Questionnaire given weekly for six weeks

Secondary Outcome Measures:

Improvement of scores on Hamilton Depression Rating Scale given weekly for six weeks
Improvement on Clinical Global Impression Severity and Improvement Scales given weekly for six weeks
Improvement of scores on MADRS (specifically item #8) given weekly for six weeks

Estimated Enrollment:	15
Study Start Date:	July 2004
Estimated Study Completion Date:	November 2007

Detailed Description:

Hypotheses:

Hypothesis 1.After wellbutrin XL addition for 6 weeks, SSRI treated subjects will show increased activation and connectivity of prefrontal cortex and limbic regions such as the amygdala on exposure to negative and positive pictures

Hypothesis 2.Increase in activation of the MRC (Mood Regulating Circuit) will correlate with decrease in Apathy Evaluation Scale (AES) score and Sexual Dysfunction Score.

We plan to study a maximum of 15 subjects in this study. SSRI treated depressed patients who after treatment of depression continue to suffer from sexual dysfunction and apathy will be included in the study. fMRI will be conducted at baseline and after addition of Wellbutrin XL treatment 300 mg po qd and then used at a dose of 300 mg - 450 mg from week 3 - 6 depending on response and tolerance. Patients will also be rated weekly on 17-item Hamilton Depression Rating Scale, Montgomery-Asberg Depression Rating Scale (MADRAS) (Montgomery and Asberg 1979), AES (Marin et al 1991), Changes in Sexual Functioning Questionnaire (CSFQ) and Clinical Global Impression (Improvement) weekly for 6 weeks. Depressed patients will also be rated on the scan days on cognitive measures such as verbal memory and working memory.

Eligibility

Ages Eligible for Study:	18 Years to 60 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Ages 18 - 60 years and able to give voluntary informed consent.
Satisfy criteria for recent treatment with for Major Depressive Episode using DSM-IV episode recently treated with an adequate dose of an SSRI (sertraline, paroxetine, fluoxetine, citalopram, escitalopram) with 17-item Hamilton Depression Rating Scale (HDRS) score < 18.
Complaining of symptoms of apathy, lack of feeling or sexual dysfunction with AES score < 10 and/or MADRAS item 8 (inability to feel > 1) and/or CSFQ score > 10
Satisfy criteria to undergo an MRI scan based on MRI screening questionnaire. 5) Able to be managed as outpatients for initial assessment and during treatment as ascertained by the following - Symptoms not worsening by more than 10 points on the HDRS during the course of the study and not representing danger to self or others.

Exclusion Criteria:

Meeting DSM-IV criteria for bipolar disorder, schizophrenia, schizophreniform disorder, schizoaffective disorder, atypical psychosis, primary anxiety disorder, mental retardation, or organic mental (including organic mood) disorder.
Use of neuroleptic in the past 1 year.
History of seizure disorder
History of eating disorders such as bulimia or anorexia nervosa
History of lack of response or intolerance to bupropion.
Use of mood stabilizers in the past 2 weeks.
Use of benzodiazepines in the past 2 weeks.
Acutely suicidal or homicidal or requiring inpatient treatment.
Meeting DSM-IV criteria for other substance dependence, including alcohol within the 6 months, except caffeine or nicotine. The criteria will be evaluated by interview and urinary toxicology screening initially and on test days.
Use of alcohol in the past 1 week.
No serious medical or neurological illness as assessed by physical examination and laboratory examination including CBC and blood chemistry.
Abnormal TSH values. If on synthroid should be on a stable dose for 3 months prior to the study with no changes during the study.
Current pregnancy or breast-feeding.
Metallic implants.
Previously known positive HIV blood test (as latent central dysfunction may be present) as reported by the subject.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00456820

Locations

United States, Indiana
Indiana University Adult Psychiatry Clinic
Indianapolis, Indiana, United States, 46202

Sponsors and Collaborators

Indiana University School of Medicine

Investigators

Principal Investigator:

Amit Anand, MD

Indiana University School of Medicine

More Information

No publications provided

Study ID Numbers:	0406-27, 45-870-26
Study First Received:	September 14, 2005
Last Updated:	October 15, 2007
ClinicalTrials.gov Identifier:	NCT00456820 History of Changes
Health Authority:	United States: Institutional Review Board

Keywords provided by Indiana University:

Mood Regulating Circuit
SSRI
fMRI

Study placed in the following topic categories:

Dopamine Uptake Inhibitors
Neurotransmitter Agents
Dopamine
Depression
Bupropion
Psychotropic Drugs

Dopamine Agents
Antidepressive Agents, Second-Generation
Depressive Disorder
Serotonin Uptake Inhibitors
Antidepressive Agents
Behavioral Symptoms

Additional relevant MeSH terms:

Dopamine Uptake Inhibitors
Neurotransmitter Uptake Inhibitors
Neurotransmitter Agents
Depression
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Psychotropic Drugs
Pharmacologic Actions

Behavioral Symptoms
Therapeutic Uses
Bupropion
Dopamine Agents
Antidepressive Agents, Second-Generation
Central Nervous System Agents
Antidepressive Agents

ClinicalTrials.gov processed this record on September 02, 2009