Inclusion Criteria:

• Patients must have cytologic or histologic confirmation of carcinoma arising in the pancreas.
• Patients must be deemed resectable or borderline resectable based on criteria in section 4.2 prior to registration.
• Patients must have an expected life expectancy of at least 12 weeks and a Zubrod performance status of < 2.
• Patients must have adequate organ function defined as follows: absolute neutrophil count of > 1500/mm3, platelets > 100,000/mm3, serum Cr < 1.5 mg/dl, total bilirubin < 3.0 mg/dl with relief of biliary obstruction if present (PTC tube or endobiliary stent).
• Patients must be free of other active systemic malignancy, ongoing infection, including HIV infection, or any other serious uncontrolled, concomitant systemic disorders or psychiatric condition that would interfere with the safe delivery of protocol therapy.
• Patients must be aware of the investigational nature of the therapy and provide written informed consent.
• Patients must have no history of previous chemotherapy for pancreatic cancer or any abdominal radiation therapy.
• Patients must not have used any investigational agent in the month before enrollment into the study.

Exclusion Criteria:

• Patients with neuroendocrine tumors are excluded.
• Patients with preexisting peripheral neuropathy > grade 2 are ineligible.
• Pregnant or nursing women are ineligible and patients of reproductive potential must agree to use an effective contraceptive method during participation in this trial and for 6 months after trial.