Oxytocin (Oxt) Transgenics
Rat oxytocin gene expressed in mice (I)
Rat oxytocin gene expressed in mice (II)
Mice that express green fluorescent protein (GFP) in oxytocin neurons†
Targeting of GFP to secretory granules, and subsequent stimulated release†
Review with tables of various transgenic lines we generated (PDF)
Oxytocin (Oxt) Knockout†
Initial description of mice lacking functional oxytocin
Initial behavioral studies
Mammary gland involution
Mammary gland development
Sociability
Role in Bruce Effect (pregnancy block)
Role in prepulse inhibition of the startle reflex
Role in social recognition
Some studies from other labs using these mice
Oxytocin Receptor (Oxtr) Knockout - conditional†
Initial description of a conditional knockout of the oxytocin receptor
Role in social recognition
Vasopressin 1a Receptor (Avpr1a) Knockout
Our initial characterization
Role in ethanol intoxication
Role in Bruce Effect (pregnancy block)
Vasopressin 1b Receptor (Avpr1b) Knockout†
Initial description of the vasopressin 1b receptor knockout mice
Reduced social motivation
Avpr1b localization to the hippocampal area CA2 pyramidal neurons
Role in ethanol intoxication
Role in social and predatory attack behaviors and defense
Role in response to restraint and hypoglycemic stresses
Role in response to LPS and ethanol stresses
Sociability
Role in Bruce Effect (pregnancy block)
Impairment of Memory for Temporal Order
Some studies from other labs using these mice
† Line is available from the Jackson Laboratories:
Oxt-eGFP | Oxt KO | Conditional Oxtr KO | Avpr1b KO
PDF versions are available for some of the articles at the selected SNGE Bibliography
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