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Sponsors and Collaborators: |
Pediatric Oncology Group National Cancer Institute (NCI) |
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Information provided by: | National Cancer Institute (NCI) |
ClinicalTrials.gov Identifier: | NCT00003811 |
RATIONALE: Chemotherapy drugs use different ways to stop tumor cells from dividing so they stop growing or die.
Chemoprotective drugs such as amifostine may protect normal cells from the side effects of chemotherapy.
PURPOSE: Phase I trial to study the effectiveness of high-dose cisplatin, etoposide, and bleomycin plus amifostine in treating children who have malignant germ cell tumors.
Condition | Intervention | Phase |
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Childhood Germ Cell Tumor Drug/Agent Toxicity by Tissue/Organ Extragonadal Germ Cell Tumor Ovarian Cancer |
Biological: bleomycin sulfate Drug: amifostine trihydrate Drug: cisplatin Drug: etoposide Procedure: conventional surgery |
Phase I |
Study Type: | Interventional |
Study Design: | Treatment |
Official Title: | High-Dose Cisplatin, Etoposide and Bleomycin (HD-PEB) Combined With Amifostine in Children With High-Risk Malignant Germ Cell Tumors - A POG Pilot Study |
Estimated Enrollment: | 25 |
Study Start Date: | April 2000 |
OBJECTIVES: I. Evaluate the early efficacy and toxicity profile of high-dose cisplatin, etoposide, bleomycin, and amifostine in children with newly diagnosed, high-risk malignant, extragonadal germ cell tumors. II. Determine whether the use of amifostine can reduce the hematologic and nonhematologic toxic effects of this combination chemotherapy in these patients when compared to similar patients treated on POG-9049/CCG-8881 with the same combination chemotherapy. III. Determine the response rate of patients treated with this regimen.
OUTLINE: Patients undergo surgical biopsy or resection. Patients then receive bleomycin IV over 10 minutes on day
1 and etoposide IV over 1 hour, amifostine IV over 15 minutes, and cisplatin IV over 1 hour on days 1-5.
Treatment repeats every 3-4 weeks for 4 courses in the absence of unacceptable toxicity or disease progression.
Patients who have no disease after 4 courses of chemotherapy receive no further treatment. Patients who have residual disease undergo second-look surgery. After surgery, patients who still have active tumor receive 2 additional courses of chemotherapy. Those patients who still have tumor after the 2 additional courses may have a third surgery. Patients are followed every month for 6 months, every 2 months for 6 months, every 6 months for 1 year, and then annually thereafter until death.
PROJECTED ACCRUAL: A total of 25 patients will be accrued for this study within 1.39 years.
Ages Eligible for Study: | up to 14 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS: Histologically confirmed, newly diagnosed, high-risk, extracranial germ cell tumors including the following: Yolk sac carcinoma (endodermal sinus tumor) Embryonal carcinoma Choriocarcinoma Teratoma with mixed malignant elements (malignant teratoma) OR Malignant recurrence (stage III or IV) of previously resected stage I extracranial, extragonadal tumor High-risk disease defined as stage III or IV extragonadal tumors Measurable disease by diagnostic imaging
PATIENT CHARACTERISTICS: Age: Under 15 at time of diagnosis Performance status: Not specified Life expectancy:
Not specified Hematopoietic: Absolute neutrophil count greater than 750/mm3 Platelet count greater than 75,000/mm3 Hepatic: Not specified Renal: Creatinine normal OR Glomerular filtration rate at least 50% of normal
PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior chemotherapy Endocrine therapy: Not specified Radiotherapy: No prior radiotherapy Surgery: See Disease Characteristics
Study Chair: | Neyssa M. Marina, MD | Stanford University |
Study ID Numbers: | CDR0000066956, POG-9749 |
Study First Received: | November 1, 1999 |
Last Updated: | May 9, 2009 |
ClinicalTrials.gov Identifier: | NCT00003811 History of Changes |
Health Authority: | United States: Federal Government |
drug/agent toxicity by tissue/organ childhood teratoma childhood malignant testicular germ cell tumor |
childhood malignant ovarian germ cell tumor childhood extragonadal germ cell tumor recurrent childhood malignant germ cell tumor |
Radiation-Protective Agents Gonadal Disorders Urogenital Neoplasms Ovarian Diseases Etoposide phosphate Genital Diseases, Female Anti-Bacterial Agents Cisplatin Neoplasms, Germ Cell and Embryonal Ovarian Cancer Etoposide Endocrine Gland Neoplasms Extragonadal Germ Cell Tumor |
Ovarian Neoplasms Testicular Cancer Amifostine Malignant Germ Cell Tumor Genital Neoplasms, Female Endocrine System Diseases Testicular Neoplasms Bleomycin Recurrence Radiation-Sensitizing Agents Endocrinopathy Antineoplastic Agents, Phytogenic Teratoma |
Radiation-Protective Agents Gonadal Disorders Antineoplastic Agents Physiological Effects of Drugs Urogenital Neoplasms Ovarian Diseases Antibiotics, Antineoplastic Genital Diseases, Female Neoplasms by Site Cisplatin Neoplasms, Germ Cell and Embryonal Therapeutic Uses Etoposide |
Endocrine Gland Neoplasms Neoplasms by Histologic Type Ovarian Neoplasms Amifostine Genital Neoplasms, Female Endocrine System Diseases Bleomycin Protective Agents Pharmacologic Actions Adnexal Diseases Neoplasms Radiation-Sensitizing Agents Antineoplastic Agents, Phytogenic |