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Sponsored by: |
Russian Academy of Medical Sciences |
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Information provided by: | Russian Academy of Medical Sciences |
ClinicalTrials.gov Identifier: | NCT00327366 |
The study investigated whether bright artificial light may influence menstrual cycle and ovulation conclusively, and what underlying hormonal changes for this effect are.
Condition | Intervention |
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Anovulation |
Procedure: Light therapy |
Study Type: | Interventional |
Study Design: | Non-Randomized, Single Blind, Placebo Control, Crossover Assignment, Efficacy Study |
Study Start Date: | September 2003 |
Estimated Study Completion Date: | November 2003 |
Several studies have shown a shortening of the menstrual cycle following light therapy in women with abnormally long menstrual cycles or with winter depression, which suggests that bright light may influence sex hormones and ovulation. The study was designed to investigate this possibility. Twenty-two women with slightly lengthened menstrual cycles and without clinically evident endocrine abnormalities completed a study lasting for two menstrual cycles separated by an off-protocol episode of at least 1 menstrual cycle. Bright light therapy was administered for a week at home during one experimental cycle, and dim light during another cycle (placebo-controlled, crossover, counter-balanced order). Daytime blood sampling and ultrasound scan were performed before and after a week of light therapy, on the ~7th and 14th days after menstruation onset.
Ultrasound examination was repeated further to document ovulation. Serum was assayed for thyroid-stimulating hormone, prolactin, luteinizing hormone, follicle-stimulating hormone, and estradiol. The preliminary results were reported at the SLTBR meeting in June, 2005.
Ages Eligible for Study: | 19 Years to 40 Years |
Genders Eligible for Study: | Female |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | M-s3 |
Study First Received: | May 17, 2006 |
Last Updated: | November 29, 2006 |
ClinicalTrials.gov Identifier: | NCT00327366 History of Changes |
Health Authority: | Russia: Pharmacological Committee, Ministry of Health |
Menstrual Cycle Light Therapy Sex Hormones Ovulation |
Genital Diseases, Female Gonadal Disorders Endocrine System Diseases Endocrinopathy |
Ovarian Diseases Anovulation Hormones |
Genital Diseases, Female Gonadal Disorders Endocrine System Diseases |
Ovarian Diseases Anovulation Adnexal Diseases |