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Pediatric HIV/AIDS Surveillance (through 2007)
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Slide 1: Reported AIDS in Children <13 Years of Age by Transmission Category, 2007 and Cumulative, United States and Dependent Areas In 2007, 87 children with AIDS were reported to CDC. Most (84%) of these children acquired HIV infection perinatally, that is, from their mother during pregnancy, labor and delivery, or through breast feeding. Since the beginning of the AIDS epidemic, 9,590 children have been reported with AIDS. Most of these children (92%) were infected perinatally. Another 4% acquired HIV from a transfusion of blood or blood products, and another 2% acquired HIV from transfusion because of hemophilia.
Slide 1
Reported AIDS in Children <13 Years of Age by Transmission Category, 2007 and Cumulative, United States and Dependent Areas
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Slide 2: Estimated Numbers of Perinatally Acquired AIDS Cases, by Year of Diagnosis, 1985–2007—United States and Dependent Areas The estimated number of AIDS cases diagnosed among persons perinatally exposed to HIV peaked in 1992 and has decreased in recent years. The decline in these cases is likely associated with the implementation of Public Health Service guidelines for the universal counseling and voluntary HIV testing of pregnant women and the use of antiretroviral therapy for pregnant women and newborn infants (MMWR 2002;51(No. RR-18)). Other contributing factors are the effective treatment of HIV infections that slow progression to AIDS and the use of prophylaxis to prevent AIDS opportunistic infections among children.
Slide 2
Estimated Numbers of Perinatally Acquired AIDS Cases, by Year of Diagnosis, 1985–2007—United States and Dependent Areas
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Slide 3: Zidovudine Use for HIV-infected Pregnant Women or for Perinatally Exposed* or Infected Children Born, 1993–2007—53 Areas In April 1994, the Public Health Service released guidelines for the use of zidovudine (ZDV) to reduce perinatal HIV transmission; in 1995, recommendations for HIV counseling and voluntary testing for pregnant women were published, and in 2002 recommendations on the use of antiretroviral drugs in pregnant, HIV-infected women were updated. Since 1994, the percentage of perinatally HIV-exposed or infected children who received ZDV or whose mother had received ZDV has increased markedly. This increase in ZDV use, including receipt by the mother during the prenatal or the intrapartum period and receipt by the neonate, has been accompanied by a decrease in the number of perinatally HIV-infected children and is responsible for the dramatic decline in perinatally acquired AIDS. Note: In 2007, the District of Columbia and the following 47 states and 5 US dependent areas conducted HIV case surveillance and reported cases of HIV infection in adults, adolescents, and children to CDC: Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Georgia, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Utah, Virginia, Washington, West Virginia, Wisconsin, Wyoming, American Samoa, Guam, the Northern Mariana Islands, Puerto Rico, and the U.S. Virgin Islands. In 2007, the following 31 states and 2 U.S. dependent areas reported perinatal exposure to HV infection to CDC: Alabama, Arizona, Arkansas, Colorado, Connecticut, Florida, Georgia, Indiana, Iowa, Kansas, Louisiana, Michigan, Minnesota, Mississippi, Missouri, Nebraska, Nevada, New Jersey, New Mexico, New York, Ohio, Oklahoma, Pennsylvania, South Carolina, Tennessee, Texas, Utah, Virginia, West Virginia, Wisconsin, Wyoming, Puerto Rico, and U.S. Virgin Islands.
Slide 3
 Zidovudine Use for HIV-infected Pregnant Women or for Perinatally Exposed* or Infected Children Born, 1993–2007—53 Areas
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Slide 4: Reported AIDS Cases in Children <13 Years of Age at Diagnosis, 2007—United States and Dependent Areas, N=87* In 2007, a total of 87 AIDS cases were reported in children younger than 13 years of age. Most of these cases were perinatally acquired. Florida and New York reported the largest number of cases. Thirty-one states did not report any pediatric AIDS cases.
Slide 4
Reported AIDS Cases in Children <13 Years of Age at Diagnosis, 2007—United States and Dependent Areas, N=87*
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Slide 5: Reported Perinatally Acquired AIDS Cases, by Age at Diagnosis Cumulative through 2007—United States and Dependent Areas Since the beginning of the epidemic, nearly 39% of children (<13 years) reported with perinatally acquired AIDS were diagnosed within the first year of life and for 22% within the first 6 months. This distribution could change if more HIV-infected childbearing women become aware of their HIV status and seek medical care early in their infant’s life, when treatment could possibly prevent the progression from HIV infection to AIDS in their children.
Slide 5
Reported Perinatally Acquired AIDS Cases, by Age at Diagnosis Cumulative through 2007—United States and Dependent Areas
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Slide 6: Children <13 Years of Age Reported to be Living with HIV Infection (not AIDS)* or with AIDS, as of December 2007—United States and Dependent Areas As of December 31, 2007, 2,527 children were reported to be living with HIV infection (not AIDS) from 53 areas (47 states, the District of Columbia, and 5 U.S. dependent areas) that conducted confidential name-based HIV infection case surveillance in 2007. An additional 881 children in the United States and dependent areas were reported to be living with AIDS. Note: In 2007, the District of Columbia and the following 47 states and 5 US dependent areas conducted HIV case surveillance and reported cases of HIV infection in adults, adolescents, and children to CDC: Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Georgia, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Utah, Virginia, Washington, West Virginia, Wisconsin, Wyoming, American Samoa, Guam, the Northern Mariana Islands, Puerto Rico, and the U.S. Virgin Islands.
Slide 6
Slide 6: Children <13 Years of Age Reported to be Living with HIV Infection (not AIDS)* or with AIDS, as of December 2007—United States and Dependent Areas
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Slide 7: AIDS-defining Conditions Most Commonly Reported for Children <13 Years of Age, Cumulative through 2007, United States and Dependent Areas Certain clinical conditions are used to define AIDS among persons infected with HIV. The most commonly reported conditions for children with AIDS are listed on this slide. From the beginning of the epidemic through 2007, 35% of children with AIDS had a diagnosis of Pneumocystis jirovecii, 23% a diagnosis of lymphoid interstitial pneumonitis, and 21% had recurrent bacterial infections.
Slide 7
 AIDS-defining Conditions Most Commonly Reported for Children <13 Years of Age, Cumulative through 2007, United States and Dependent Areas
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Slide 8: AIDS-defining Conditions for Reported Perinatally Acquired AIDS Cases, by Age at Diagnosis, Cumulative through 2007—United States and Dependent Areas The incidence of Pneumocystis jirovecii in children with perinatally acquired AIDS peaks at 5 months of age. The age at diagnosis for the other AIDS-defining conditions is much more evenly distributed during the first 2 years of life. Because Pneumocystis jirovecii occurs early, prophylaxis is recommended for all perinatally HIV-exposed children, beginning at 6 weeks of age. The occurrence of Pneumocystis jirovecii in children may indicate missed opportunities for testing pregnant women, the use of zidovudine or other antiretroviral therapies to prevent transmission, or therapy for HIV-exposed children. CDC has a high-priority initiative to reduce HIV transmission from mothers to children by promoting voluntary prenatal maternal HIV testing (intrapartum if women do not receive prenatal care) and antiretroviral therapy.
Slide 8
AIDS-defining Conditions for Reported Perinatally Acquired AIDS Cases, by Age at Diagnosis, Cumulative through 2007—United States and Dependent Areas
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Slide 9: Percentages of AIDS Cases and Population among Children <13 Years of Age, by Race/Ethnicity 2007—50 States and DC AIDS has disproportionately affected black/African American children in the United States. Although only 14% of children in the United States are black/African American, 73% of children reported with AIDS in 2007 were black/African American. The percentages of cases among American Indian/Alaska Native, Asian, Hispanic/Latino, Native Hawaiian/Other Pacific Islander, and white children are lower than the percentages of children of these races/ethnicities in the total population.
Slide 9
 Percentages of AIDS Cases and Population among Children <13 Years of Age, by Race/Ethnicity 2007—50 States and DC
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Slide 10: AIDS Rates for Children <13 Years of Age by Race/Ethnicity, Reported in 2007—50 States and DC Black/African American children had the highest rate (0.8 per 100,000) of AIDS among children in 2007. Because most pediatric cases of AIDS are attributed to perinatal HIV transmission, these rates also reflect the disproportionate racial/ethnic distribution of HIV and AIDS among black/African American women in the United States.
Slide 10
AIDS Rates for Children <13 Years of Age by Race/Ethnicity, Reported in 2007—50 States and DC
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Slide 11: Time of Maternal HIV Testing among Children with Perinatally Acquired AIDS, HIV Exposure or HIV Infection Reported in 2007—United States and Dependent Areas It is important for HIV-infected pregnant women to know their HIV infection status in order to make informed decisions about antiretroviral therapy to reduce perinatal transmission of HIV to their infants. The Public Health Service recommends that all pregnant women be offered HIV counseling and voluntary HIV tests. For children reported to CDC in 2007 as perinatally exposed to HIV, 95% were born to women who were tested before or at the time of birth. For children who were perinatally HIV-infected, 40% of them had a mother who was tested before or at the time of birth; among children diagnosed with AIDS, 38% were born to mothers who were tested before or at the time of birth. An additional 26% of children reported with HIV infection (not AIDS) and 40% of children with AIDS were born to mothers tested after the child’s birth. These data demonstrate that early testing and, therefore, the increased potential for ZDV therapy to prevent transmission can help to reduce HIV transmission to children by their mothers. Note: In 2007, the District of Columbia and the following 47 states and 5 US dependent areas conducted HIV case surveillance and reported cases of HIV infection in adults, adolescents, and children to CDC: Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Georgia, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Utah, Virginia, Washington, West Virginia, Wisconsin, Wyoming, American Samoa, Guam, the Northern Mariana Islands, Puerto Rico, and the U.S. Virgin Islands. In 2007, the following 31 states and 2 U.S. dependent areas reported perinatal exposure to HV infection to CDC: Alabama, Arizona, Arkansas, Colorado, Connecticut, Florida, Georgia, Indiana, Iowa, Kansas, Louisiana, Michigan, Minnesota, Mississippi, Missouri, Nebraska, Nevada, New Jersey, New Mexico, New York, Ohio, Oklahoma, Pennsylvania, South Carolina, Tennessee, Texas, Utah, Virginia, West Virginia, Wisconsin, Wyoming, Puerto Rico, and U.S. Virgin Islands.
Slide 11
Time of Maternal HIV Testing among Children with Perinatally Acquired AIDS, HIV Exposure or HIV Infection Reported in 2007—United States and Dependent Areas
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Last Modified: May 19, 2009
Last Reviewed: May 19, 2009
Content Source:
Divisions of HIV/AIDS Prevention
National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention
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