Effects of Sleep Loss on Endothelial Function and Cytokine Levels in Internal Medicine Residents - Full Text View

Sponsors and Collaborators:	Yale University National Heart, Lung, and Blood Institute (NHLBI) National Center for Research Resources (NCRR)
Information provided by:	Yale University
ClinicalTrials.gov Identifier:	NCT00272233

Purpose

Work requirements for medical trainees result in substantial sleep loss. Sleep loss has been associated with increased levels of certain inflammatory hormones that could have negative impact on blood vessel function. The purpose of this study is to determine the effects of sleep loss on blood hormone levels and blood vessel function in medical trainees.

Condition	Phase
Sleep Deprivation	Phase I

Study Type:	Observational
Study Design:	Natural History, Longitudinal, Defined Population, Prospective Study
Official Title:	Effects of Sleep Loss on Endothelial Function and Cytokine Levels in Internal Medicine Residents

Further study details as provided by Yale University:

Estimated Enrollment:	22
Study Start Date:	December 2004
Estimated Study Completion Date:	June 2005

Detailed Description:

Context: Sleep loss is associated with increased blood levels of interleukin-6 (IL-6) and C-reactive protein (CRP). Medical residents are often deprived of normal sleep during extended work shifts, but the effects of work-related sleep loss on biomarkers of vascular inflammation and function are unknown.

Objective: We sought to test the hypothesis that sleep loss during extended work shifts during medical training is associated with increased circulating levels of pro-inflammatory biomarkers and evidence of vascular dysfunction.

Design: Outcome measures were assessed after extended 30-hour work shifts and non-extended 6-hour work shifts in a single-blind, randomized crossover design.

Setting: University hospital medical intensive care unit

Patients or Other Participants: Twenty-two healthy medical residents were studied during a medical intensive care unit rotation.

Main Outcome Measure(s): Sleep related cytokines (interleukin-6 and tumor necrosis factor), serum markers of vascular inflammation (C-reactive protein), and flow-mediated dilation in the brachial artery.

Eligibility

Ages Eligible for Study:	18 Years to 40 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Medical resident in MICU rotation
Non-smoker
Body mass index <28 kg/m2

Exclusion Criteria:

Systolic blood pressure >140 mmHg; Diastolic blood pressure >90 mmHg
Known history of diabetes mellitus, hypertension, hyperlipidemia
Known history of acute or chronic inflammatory or infectious disease
Known history of sleep disturbance unrelated to work
Pregnancy

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00272233

Locations

United States, Connecticut
Yale University School of Medicine
New Haven, Connecticut, United States, 06510

Sponsors and Collaborators

Yale University

National Heart, Lung, and Blood Institute (NHLBI)

National Center for Research Resources (NCRR)

Investigators

Principal Investigator:

Stuart D Katz, MD

Yale University

More Information

No publications provided

Study ID Numbers:	HIC26414, NIH NHLBI K24 04024
Study First Received:	January 3, 2006
Last Updated:	March 19, 2007
ClinicalTrials.gov Identifier:	NCT00272233 History of Changes
Health Authority:	United States: Yale University School of Medicine; United States: National Heart Lung and Blood Institute

Keywords provided by Yale University:

Inflammation Mediators [D23.469]
Cardiovascular Physiologic Phenomena [G09.330.553]

Study placed in the following topic categories:

Signs and Symptoms
Mental Disorders
Neurologic Manifestations
Sleep Disorders

Dyssomnias
Sleep Deprivation
Inflammation

Additional relevant MeSH terms:

Signs and Symptoms
Mental Disorders
Nervous System Diseases
Neurologic Manifestations

Sleep Disorders
Dyssomnias
Sleep Deprivation

ClinicalTrials.gov processed this record on September 01, 2009