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Sponsors and Collaborators: |
Rockefeller University National Institute of Allergy and Infectious Diseases (NIAID) New York Presbyterian Hospital |
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Information provided by: | Rockefeller University |
ClinicalTrials.gov Identifier: | NCT00219999 |
The purpose of this study is to measure specific chemokines, antibodies, and antibody-producing B cells in the blood of patients with hepatitis C virus (HCV) infection. Our hypothesis is that changes in chemokine levels affect the development of an effective immune response against HCV.
Condition |
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Hepatitis C Virus |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Hepatitis C Virus and the Humoral Immune System |
whole blood
Estimated Enrollment: | 810 |
Study Start Date: | September 2001 |
Estimated Study Completion Date: | May 2011 |
Groups/Cohorts |
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HCV infection
current HCV infection, including intravenous drug users
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cryoglobulinemia
cryoglobulinemia and without HCV infection
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chronic liver disease
chronic liver disease not due to hepatitis C virus infection
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Sustained Virologic responders
successfully treated for HCV infection
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normal
normal, healthy volunteers
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The long-term goal of our research is to understand why immune complexes (ICs) are produced in patients infected with HCV, and whether these complexes affect virus interaction with target cells. We have found that many patients infected with HCV have an increased frequency of circulating B cells, but no evidence that the increased B cells are activated of proliferating. One possible mechanism for such an increase would be a change in levels of chemokines that influence B cell localization and trafficking. Our studies are aimed at testing the following hypotheses:
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
primary care clinics of doctors at NYPH and the NYC metropolitan area
Inclusion Criteria:
Exclusion Criteria:
Contact: Lynn B Dustin, PHD | 212-327-7067 |
United States, New York | |
Rockefeller University Hosital | Recruiting |
New York, New York, United States, 10021 | |
Contact: Lynn B Dustin, PHD 212-327-7067 | |
Principal Investigator: Lynn B Dustin, PHD |
Principal Investigator: | Lynn B Dustin, PHD | Rockefeller University |
Responsible Party: | Rockefeller University ( Lynn Dustin, PhD ) |
Study ID Numbers: | LDU-0437, R01AI60561 |
Study First Received: | September 19, 2005 |
Last Updated: | June 24, 2009 |
ClinicalTrials.gov Identifier: | NCT00219999 History of Changes |
Health Authority: | United States: Institutional Review Board |
Hepatitis Hepacivirus B Lymphocytes Chemokines Antibodies |
Virus Diseases Hepatitis Antibodies Liver Diseases |
Digestive System Diseases Hepatitis, Viral, Human Hepatitis C Immunoglobulins |
Virus Diseases Hepatitis RNA Virus Infections Liver Diseases |
Digestive System Diseases Flaviviridae Infections Hepatitis, Viral, Human Hepatitis C |