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Sponsors and Collaborators: |
National Institute on Drug Abuse (NIDA) Johns Hopkins University |
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Information provided by: | National Institute on Drug Abuse (NIDA) |
ClinicalTrials.gov Identifier: | NCT00218010 |
Methadone is a drug that offers significant therapeutic benefits to opiate dependent women who are pregnant.
Currently, it is the treatment of choice for this group of people. The purpose of this study is to determine the amount of methadone in the breast milk of women who are breastfeeding and taking methadone for opiate addiction.
In addition, this study will evaluate the effects of methadone on infant neurobehavior.
Condition |
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Breast Feeding Opioid-Related Disorders |
Study Type: | Observational |
Study Design: | Screening, Longitudinal, Case Control, Prospective Study |
Official Title: | Breastfeeding Among Methadone Maintained Women |
Estimated Enrollment: | 25 |
Study Start Date: | November 2000 |
Estimated Study Completion Date: | September 2005 |
Methadone is a drug that is commonly used to treat opiate addiction, usually as part of a detoxification and maintenance program. Methadone offers significant therapeutic benefits to pregnant women who are opiate dependent, and it is currently the treatment of choice for this group of people. In general, breast milk is beneficial for infants. However, there is some concern as to whether it is safe for women who are taking methadone to breastfeed their babies. The purpose of this study is to determine the amount of methadone in the breast milk of women who are breastfeeding and taking methadone for opiate addiction. In addition, this study will evaluate the effects of methadone on infant neurobehavior.
Participants will be assigned to one of two groups: women taking methadone who will breastfeed their babies or women taking methadone who will bottle-feed their babies. On Days 1, 2, 3, 4, 14, and 30, following infant delivery, plasma will be collected from both groups and breast milk will be collected from the breastfeeding group. These samples will be quantitatively analyzed for methadone. Infants will undergo neurobehavioral assessments on Days 3, 14, and 30, following birth. Rates and severity of neonatal abstinence syndrome will also be evaluated.
Ages Eligible for Study: | 18 Years to 40 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
United States, Maryland | |
Johns Hopkins University (BPRU) Bayview Campus | |
Baltimore, Maryland, United States, 21224 6823 |
Principal Investigator: | Lauren M. Jansson, MD | Johns Hopkins University |
Study ID Numbers: | NIDA-00495-2, K08-00495-2, DPMC |
Study First Received: | September 16, 2005 |
Last Updated: | August 2, 2006 |
ClinicalTrials.gov Identifier: | NCT00218010 History of Changes |
Health Authority: | United States: Federal Government |
Behavior, Addictive Disorders of Environmental Origin Central Nervous System Depressants Narcotics Opioid-Related Disorders Naphazoline Methadone |
Mental Disorders Guaifenesin Substance-Related Disorders Phenylpropanolamine Analgesics Peripheral Nervous System Agents Analgesics, Opioid |
Respiratory System Agents Physiological Effects of Drugs Disorders of Environmental Origin Central Nervous System Depressants Narcotics Opioid-Related Disorders Pharmacologic Actions Methadone Sensory System Agents |
Mental Disorders Therapeutic Uses Substance-Related Disorders Peripheral Nervous System Agents Analgesics Antitussive Agents Central Nervous System Agents Analgesics, Opioid |