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Sponsored by: |
University of Minnesota |
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Information provided by: | University of Minnesota |
ClinicalTrials.gov Identifier: | NCT00397436 |
The main focus of this pilot study is to construct a fairly complete protein profile of the epidermis. This will allow us to study how the epidermis responds to external stressors such as ultra-violet. We hypothesize that by using the cutting edge technology, proteomics, we will be able to construct a fairly complete profile of different epidermal cells (keratinocytes, epidermal nerve fibers (ENFs), melanocytes, Langerhans cell,...etc) of normal and ultraviolet (UV) irradiated skin.
Condition | Intervention | Phase |
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Proteomics |
Procedure: UV Irradiation |
Phase 0 |
Study Type: | Interventional |
Study Design: | Diagnostic, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment |
Official Title: | Pilot Study of Protein Profiling of the Human Epidermal Cells After Ultraviolet Irradiation |
Estimated Enrollment: | 60 |
Study Start Date: | February 2007 |
Estimated Study Completion Date: | November 2009 |
Estimated Primary Completion Date: | November 2009 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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1: Experimental
Comparing irradiated skin to non irradiated skin.
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Procedure: UV Irradiation
UV irradiation
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We will investigate the changes of the epidermal cell proteome after UV irradiation to the forearms of healthy young male volunteers. Knowledge of specific molecular markers may provide knowledge of basic biological systems and possibly targeted therapy of inflammation. By using combined proteomic methodologies we will be able to quantify protein changes at cytoplasmic and membrane protein levels of epidermal cells in normal vs. irradiated skins. This study may allow us to obtain fairly comprehensive profile of membrane integrated and cytoplasmic proteins of epidermal cell populations which will facilitate our understand of biological responses to UV irradiation.
Ages Eligible for Study: | 18 Years to 30 Years |
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
United States, Minnesota | |
University of Minnesota | |
Minneapolis, Minnesota, United States, 55455 |
Principal Investigator: | George Wilcox, PhD | University of Minnesota |
Responsible Party: | University of Minnesota ( George Wilcox ) |
Study ID Numbers: | 0506M70827 |
Study First Received: | November 7, 2006 |
Last Updated: | August 12, 2009 |
ClinicalTrials.gov Identifier: | NCT00397436 History of Changes |
Health Authority: | United States: Institutional Review Board |