Improvement in Baroreflex Sensitivity in OSAS

This study is currently recruiting participants.

Verified by Nagoya University, May 2005

First Received: January 27, 2006 No Changes Posted

Sponsored by:	Nagoya University
Information provided by:	Nagoya University
ClinicalTrials.gov Identifier:	NCT00284037

Purpose

Individuals with obstructive sleep apnea syndrome (OSAS) are at high risk for cardiovascular morbidity and mortality. The effect of long-term nocturnal therapy with continuous positive airway pressure (CPAP) on daytime baroreflex sensitivity (BRS), a predictor of cardiac death, was investigated in OSAS patients.

Condition	Intervention
Obstructive Sleep Apnea Syndrome	Device: continuous positive airway pressure therapy

Study Type:	Interventional
Study Design:	Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study

Resource links provided by NLM:

MedlinePlus related topics: Sleep Apnea

U.S. FDA Resources

Eligibility

Ages Eligible for Study:	20 Years to 70 Years
Genders Eligible for Study:	Both

Criteria

Inclusion Criteria:

obstructive sleep apnea syndrome

Exclusion Criteria:

diabetes mellitus, chronic obstructive lung disease, coronary or valvular heart disease, congestive heart failure, renal failure, or endocrine dysfunction. Moreover, none of them were taking b-blockers, vasodilators, or inotropic agents at the time of enrollment in the study.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00284037

Contacts

Contact: Akiko Noda, PhD

+81-52-719-1537

a-noda@met.nagoya-u.ac.jp

Locations

Japan
Nagoya University of Health Sciences	Recruiting
Nagoya, Japan, 461-8673
Contact: Akiko Noda, PhD +81-719-1537 a-noda@met.nagoya-u.ac.jp
Principal Investigator: Akiko Noda, PhD

Sponsors and Collaborators

Nagoya University

Investigators

Study Chair:

Mitsuhiro Yokota, MD.PhD

Department of Cardiovascular Genome Science, Nagoya University School of Medicine, Nagoya, Aichi, Japan

More Information

No publications provided

Study ID Numbers:	NU-06-A-0003
Study First Received:	January 27, 2006
Last Updated:	January 27, 2006
ClinicalTrials.gov Identifier:	NCT00284037 History of Changes
Health Authority:	Japan: Ministry of Health, Labor and Welfare

Keywords provided by Nagoya University:

obstructive sleep apnea,
baroreceptors

Study placed in the following topic categories:

Sleep Apnea Syndromes
Respiratory Tract Diseases
Apnea
Respiration Disorders

Sleep Apnea, Obstructive
Dyssomnias
Sleep Disorders
Sleep Disorders, Intrinsic

Additional relevant MeSH terms:

Sleep Apnea Syndromes
Pathologic Processes
Disease
Respiratory Tract Diseases
Apnea
Syndrome

Nervous System Diseases
Respiration Disorders
Sleep Apnea, Obstructive
Sleep Disorders
Dyssomnias
Sleep Disorders, Intrinsic

ClinicalTrials.gov processed this record on August 30, 2009