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| Sponsored by: |
Brigham and Women's Hospital |
|---|---|
| Information provided by: | Brigham and Women's Hospital |
| ClinicalTrials.gov Identifier: | NCT00833313 |
Purpose
Atrial fibrillation is a type of irregular heartbeat that is common after having heart surgery. There may be many different reasons why some people get atrial fibrillation after their heart surgery. These reasons may include that a person is older or that he/she is taking certain types of medications before surgery. Genes may also be a reason. Genes contain the material passed from parent to child that determines the make-up of the body and mind.
For example, some genes control the color of your hair or eyes. Some people may have genes that make it more likely for them to get atrial fibrillation after their heart surgery. This research project is being done to find out if the cells of people who develop atrial fibrillation after heart surgery are different from the cells in people who do not develop atrial fibrillation after surgery.
| Condition | Intervention |
|---|---|
|
Atrial Fibrillation |
Other: Atrial biopsy |
| Study Type: | Observational |
| Study Design: | Cohort, Prospective |
| Official Title: | Gene Expression Profiling in Subjects With Postoperative Atrial Fibrillation After Cardiac Surgery |
Atrial tissue sample
| Estimated Enrollment: | 240 |
| Study Start Date: | August 2008 |
| Estimated Study Completion Date: | August 2014 |
| Estimated Primary Completion Date: | August 2013 (Final data collection date for primary outcome measure) |
Atrial fibrillation is a type of irregular heartbeat that is common after having heart surgery. There may be many different reasons why some people get atrial fibrillation after their heart surgery. These reasons may include that a person is older or that he/she is taking certain types of medications before surgery. Genes may also be a reason. Genes contain the material passed from parent to child that determines the make-up of the body and mind.
For example, some genes control the color of your hair or eyes. Some people may have genes that make it more likely for them to get atrial fibrillation after their heart surgery. This research project is being done to find out if the cells of people who develop atrial fibrillation after heart surgery are different from the cells in people who do not develop atrial fibrillation after surgery.
This study seeks to identify regulatory events in atrial myocyte transcription and translation that are altered by germline variation
Eligibility| Ages Eligible for Study: | 20 Years to 80 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Adult patients undergoing cardiac surgery
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: Simon C Body, MD | 617-732-7330 | sbody@partners.org |
| Contact: Tjorvi E Perry, MD | 617-732-7330 | tperry@partners.org |
| United States, Massachusetts | |
| Brigham and Women's Hospital | Recruiting |
| Boston, Massachusetts, United States, 02115 | |
| Contact: Tjorvi E Perry, MD 617-732-7330 tperry@partners.org | |
| Sub-Investigator: Tjorvi E Perry, MD | |
| Principal Investigator: | Simon C Body, MD | Brigham and Women's Hospital |
More Information
| Responsible Party: | Brigham and Women's Hospital ( Simon C. Body, MD ) |
| Study ID Numbers: | 2008-P000896 |
| Study First Received: | January 5, 2009 |
| Last Updated: | July 30, 2009 |
| ClinicalTrials.gov Identifier: | NCT00833313 History of Changes |
| Health Authority: | United States: Institutional Review Board |
|
Atrial fibrillation Gene expression Genetic |
|
Heart Diseases Atrial Fibrillation Arrhythmias, Cardiac |
|
Pathologic Processes Heart Diseases Cardiovascular Diseases Atrial Fibrillation Arrhythmias, Cardiac |
