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Sponsored by: |
National Heart, Lung, and Blood Institute (NHLBI) |
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Information provided by: | National Heart, Lung, and Blood Institute (NHLBI) |
ClinicalTrials.gov Identifier: | NCT00541255 |
Asthma is a common disease that is often diagnosed in childhood. In some teenagers, asthma symptoms disappear and treatment can be stopped; however, for some of these people, asthma symptoms return in adulthood. This study will examine data collected over the lifetime of 18-year olds to identify factors that may increase a person's chance of having recurrent asthma as an adult.
Condition |
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Asthma Dermatitis, Atopic Rhinitis Urticaria |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | Epidemiology of Asthma and Allergic Disease: Risk and Prognosis in a Cohort From Birth to Adolescence |
Whole blood, serum, saliva, urine
Estimated Enrollment: | 1200 |
Study Start Date: | September 2007 |
Estimated Study Completion Date: | May 2011 |
Asthma is a serious, long-term illness that affects around 15% of children in the United States. During adolescence, up to 50% of teenagers stop experiencing symptoms and are able to discontinue treatment. However, asthma symptoms often reoccur in adulthood for many of these people. It is not known exactly what causes this recurrence, but potential risk factors may include obesity, elevated serum leptin levels, early onset of puberty, exposure to pollutants, parental smoking habits, and lack of breastfeeding. Additionally, it is not known why childhood asthma is initially more prevalent in boys, but during adolescence it becomes more prevalent in girls.
Beginning in 1989, a group of children born on the Isle of Wight in the United Kingdom has been followed by study researchers to provide long-term information on asthma. These children have been periodically evaluated over the years and are now 18 years old. The purpose of this study is to analyze participants' data collected over a span of 18 years to identify factors that may increase a person's risk of experiencing persistent or recurrent asthma in adulthood.
At previous study visits that occurred when participants were 1, 2, 4, and 10 years old, information on the following was collected: asthma and other allergic diseases, family history of asthma, and early life risk factors, including breastfeeding and tobacco smoke exposure. A blood sample was collected at participants' 10-year study visit. For this current study, all 18-year-old participants will return for a study visit.
Participants will complete questionnaires on asthma and allergy symptoms and environmental exposures, including tobacco smoke and pollution. Blood collection, an allergy skin prick test, lung function testing, and a bronchial challenge test to assess airway function will occur. Select participants will also have a sputum sample collected.
Ages Eligible for Study: | 17 Years to 19 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
The study population consists of around 1500 unselected subjects (now age 18) who were recruited at birth. This is a homogenous population with 99% being Caucasians.
Inclusion Criteria:
Exclusion criteria:
United Kingdom, Isle of Wight | |
The David Hide Asthma and Allergy Research Centre | |
Newport, Isle of Wight, United Kingdom, PO305TG |
Principal Investigator: | Syed Arshad, MD | University of Southampton, United Kingdom |
Responsible Party: | Isle of Wight NHS Primary Care Trust ( Dr. S. Hasan Arshad/Conusltant ) |
Study ID Numbers: | 1408, 1 R01 HL082925-01A2 |
Study First Received: | October 9, 2007 |
Last Updated: | March 5, 2009 |
ClinicalTrials.gov Identifier: | NCT00541255 History of Changes |
Health Authority: | United States: Federal Government; United Kingdom: Research Ethics Committee |
Bronchial Asthma Food Allergy Bronchial Hyperresponsiveness |
Food Hypersensitivity Otorhinolaryngologic Diseases Dermatitis, Atopic Skin Diseases Bronchial Diseases Asthma Rhinitis Urticaria Hypersensitivity Lung Diseases, Obstructive |
Respiratory Tract Infections Genetic Diseases, Inborn Respiratory Tract Diseases Lung Diseases Hypersensitivity, Immediate Skin Diseases, Eczematous Bronchial Hyperreactivity Skin Diseases, Genetic Dermatitis Respiratory Hypersensitivity |
Skin Diseases, Vascular Otorhinolaryngologic Diseases Dermatitis, Atopic Skin Diseases Bronchial Diseases Immune System Diseases Asthma Rhinitis Urticaria Nose Diseases Lung Diseases, Obstructive |
Hypersensitivity Respiratory Tract Infections Genetic Diseases, Inborn Respiratory Tract Diseases Lung Diseases Hypersensitivity, Immediate Skin Diseases, Eczematous Skin Diseases, Genetic Dermatitis Respiratory Hypersensitivity |